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Tbio
EPN1
Epsin-1

Protein Summary
Description
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000085079
  • ENSP00000085079
  • ENSG00000063245
  • ENST00000270460
  • ENSP00000270460
  • ENST00000411543
  • ENSP00000406209
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.89
disease perturbation
0.87
transcription factor
0.78
transcription factor binding site profile
0.78
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.51   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.51   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
EGFR downregulation
Reactome
Membrane Trafficking
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
EGFR downregulation
Membrane Trafficking
Signal Transduction
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (195)
1 – 10 of 195
EPN3
Tbio
Novelty: 0.14281801
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.876
Data Source: BioPlex,STRINGDB
GAS2L1
Tbio
Novelty: 0.327993
p_int: 0.999990323
p_ni: 0.000009677
Score: 0.232
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.02672907
p_int: 0.999987472
p_ni: 0.000012528
Data Source: BioPlex
KIF20A
Tchem
Novelty: 0.02093857
p_int: 0.999956127
p_ni: 0.000043868
p_wrong: 5e-9
Data Source: BioPlex
SLC2A14
Tbio
Family: Transporter
Novelty: 0.003532
p_int: 0.998045393
p_ni: 0.001954607
Score: 0.198
Data Source: BioPlex,STRINGDB
TADA2B
Tbio
Family: TF
Novelty: 0.09308511
p_int: 0.997125753
p_ni: 0.002874024
p_wrong: 2.22e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
RAB33B
Tbio
Family: Enzyme
Novelty: 0.08158789
p_int: 0.991793495
p_ni: 0.008201103
p_wrong: 0.000005403
Data Source: BioPlex
FLVCR2
Tbio
Novelty: 0.00963619
p_int: 0.98990895
p_ni: 0.01009064
p_wrong: 4.1e-7
Score: 0.382
Data Source: BioPlex,STRINGDB
PLPPR2
Tdark
Family: Enzyme
Novelty: 1.875
p_int: 0.989005207
p_ni: 0.010994729
p_wrong: 6.4e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.01240983
p_int: 0.967025472
p_ni: 0.032193139
p_wrong: 0.000781389
Score: 0.964
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  33.51

PubMed score by year
PubTator Score  28.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer