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Tbio
EPN1
Epsin-1

Protein Summary
Description
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000085079
  • ENSP00000085079
  • ENSG00000063245
  • ENST00000270460
  • ENSP00000270460
  • ENST00000411543
  • ENSP00000406209
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.89
disease perturbation
0.87
transcription factor
0.78
transcription factor binding site profile
0.78
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.4   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.4   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epsin 1
VGNC:2389
737301
Macaque
epsin 1
702956
Mouse
MGI:1333763
13854
Rat
RGD:619772
117277
Dog
epsin 1
VGNC:40419
608964
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epsin 1
Macaque
epsin 1
Mouse
Rat
Dog
epsin 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6I3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
EGFR downregulation
Reactome
Membrane Trafficking
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
EGFR downregulation
Membrane Trafficking
Signal Transduction
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (195)
1 – 10 of 195
EPN3
Tbio
Novelty: 0.12685855
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.876
Data Source: BioPlex,STRINGDB
GAS2L1
Tbio
Novelty: 0.17484834
p_int: 0.999990323
p_ni: 0.000009677
Score: 0.232
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.999987472
p_ni: 0.000012528
Data Source: BioPlex
KIF20A
Tchem
Novelty: 0.01640924
p_int: 0.999956127
p_ni: 0.000043868
p_wrong: 5e-9
Data Source: BioPlex
SLC2A14
Tbio
Family: Transporter
Novelty: 0.00247741
p_int: 0.998045393
p_ni: 0.001954607
Score: 0.198
Data Source: BioPlex,STRINGDB
TADA2B
Tbio
Family: TF
Novelty: 0.06387677
p_int: 0.997125753
p_ni: 0.002874024
p_wrong: 2.22e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
RAB33B
Tbio
Family: Enzyme
Novelty: 0.06381712
p_int: 0.991793495
p_ni: 0.008201103
p_wrong: 0.000005403
Data Source: BioPlex
FLVCR2
Tbio
Novelty: 0.02871146
p_int: 0.98990895
p_ni: 0.01009064
p_wrong: 4.1e-7
Score: 0.382
Data Source: BioPlex,STRINGDB
PLPPR2
Tdark
Family: Enzyme
Novelty: 1.03318406
p_int: 0.989005207
p_ni: 0.010994729
p_wrong: 6.4e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.967025472
p_ni: 0.032193139
p_wrong: 0.000781389
Score: 0.964
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  54.40

PubMed score by year
PubTator Score  28.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer