Protein Summary
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- ENST00000261367
- ENSP00000261367
- ENSG00000064692
- ENST00000261368
- ENSP00000261368
- ENST00000379538
- ENSP00000368854
- ENST00000395469
- ENSP00000378852
- Sph1
- SYPH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.78 | ||
histone modification site profile | 0.75 | ||
gene perturbation | 0.66 | ||
cell type or tissue | 0.65 | ||
tissue | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.46 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 206 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.46 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 206 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (72)
TTC28
Novelty: 0.16651519
p_int: 0.999848461
p_ni: 0.000151524
p_wrong: 1.5e-8
Data Source: BioPlex
RNF41
Family: Enzyme
Novelty: 0.01953473
p_int: 0.999779643
p_ni: 0.000219543
p_wrong: 8.14e-7
Data Source: BioPlex
KIAA0930
Novelty: 0.16492958
p_int: 0.99969471
p_ni: 0.000033577
p_wrong: 0.000271713
Data Source: BioPlex
PPP1CC
Family: Enzyme
Novelty: 0.00465946
p_int: 0.857539056
p_ni: 4e-9
p_wrong: 0.14246094
Score: 0.463
Data Source: BioPlex,STRINGDB
FHL2
Novelty: 0.00501273
p_int: 0.796421869
p_ni: 0.203538894
p_wrong: 0.000039238
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (2)
KEGG (1)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heart rate response to exercise | 2 | 2 | 6 | 31.3 | |||||
1 | 1 | 0 | 9 | 24.5 | |||||
heart rate response to recovery post exercise | 1 | 1 | 1 | 4.4 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heart rate response to exercise | 6 | 31.3 | |||||
0 | 9 | 24.5 | |||||
heart rate response to recovery post exercise | 1 | 4.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | synuclein alpha interacting protein | VGNC:13595 | 462021 | |||||
Macaque | synuclein alpha interacting protein | 700372 | ||||||
Mouse | MGI:1915097 | 67847 | ||||||
Rat | RGD:1309283 | 307309 | ||||||
Dog | synuclein alpha interacting protein | VGNC:46597 | 481479 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | synuclein alpha interacting protein | |||||
Macaque | synuclein alpha interacting protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | synuclein alpha interacting protein | |||||
Publication Statistics
PubMed Score 77.46
PubMed score by year
PubTator Score 66.00
PubTator score by year
Related Publications
Text Mined References (73)
GeneRif Annotations (37)
Items per page:
0 of 0
PMID | Year | Title |
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