You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATP23
Mitochondrial inner membrane protease ATP23 homolog

Protein Summary
Description
The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300145
  • ENSP00000300145
  • ENSG00000166896
  • ENST00000571490
  • ENSP00000460944
  • ENSG00000262145

Symbol
  • KUB3
  • XRCC6BP1
  • KUB3
  • XRCC6BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.93   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.93   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
p_int:  0.999999156
p_ni:  8.31e-7
p_wrong:  1.3e-8
Score:  0.489
Data Source:  BioPlex,STRINGDB
ATG7
Tchem
Novelty:  0.00120728
p_int:  0.999996741
p_ni:  0.000003259
Score:  0.203
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999995982
p_ni:  0.000003974
p_wrong:  4.4e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
ECM1
Tbio
Novelty:  0.00518679
p_int:  0.999979455
p_ni:  0.000020543
p_wrong:  1e-9
Data Source:  BioPlex
C22orf39
Tdark
Novelty:  1.13707647
p_int:  0.99996885
p_ni:  0.000001031
p_wrong:  0.000030119
Data Source:  BioPlex
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.999965835
p_ni:  0.000034164
Data Source:  BioPlex
TNNC1
Tclin
Novelty:  0.03535727
p_int:  0.999952537
p_ni:  0.000047369
p_wrong:  9.4e-8
Data Source:  BioPlex
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
p_int:  0.999918068
p_ni:  0.000040681
p_wrong:  0.000041251
Data Source:  BioPlex
CHST12
Tbio
Family:  Enzyme
Novelty:  0.04560641
p_int:  0.99988274
p_ni:  0.000076615
p_wrong:  0.000040645
Score:  0.175
Data Source:  BioPlex,STRINGDB
CD79A
Tbio
Novelty:  0.00118942
p_int:  0.999658571
p_ni:  0.000242091
p_wrong:  0.000099338
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
2
1
6.8
53.7
mathematical ability
1
1
1
24.5
self reported educational attainment
1
1
1
13.5
cognitive function measurement
1
1
1
12.9
hematocrit
1
1
1
11.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6.8
53.7
mathematical ability
1
24.5
self reported educational attainment
1
13.5
cognitive function measurement
1
12.9
hematocrit
1
11.4
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP23 metallopeptidase and ATP synthase assembly factor homolog
VGNC:12791
452031
Mouse
MGI:1916984
68876
Rat
RGD:1588587
299828
Dog
ATP23 metallopeptidase and ATP synthase assembly factor homolog
VGNC:38252
474422
Horse
ATP23 metallopeptidase and ATP synthase assembly factor homolog
VGNC:15649
100054108
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP23 metallopeptidase and ATP synthase assembly factor homolog
Mouse
Rat
Dog
ATP23 metallopeptidase and ATP synthase assembly factor homolog
Horse
ATP23 metallopeptidase and ATP synthase assembly factor homolog
Publication Statistics
PubMed Score 10.93
PubMed score by year
PubTator Score 3.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title