You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CHCHD2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

Protein Summary
Description
Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In respon ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395422
  • ENSP00000378812
  • ENSG00000106153

Symbol
  • C7orf17
  • MNRR1
  • NS2TP
  • MIX17B
  • PARK22
  • C7orf17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.96
virus perturbation
0.92
transcription factor binding site profile
0.83
histone modification site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.52   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.52   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
11
19
94.4
glycine measurement
3
2
3
90.8
blood metabolite measurement
2
1
2
69.8
serum alanine aminotransferase measurement
2
2
1
7
56.8
metabolite measurement
1
1
1
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
19
94.4
glycine measurement
3
90.8
blood metabolite measurement
2
69.8
serum alanine aminotransferase measurement
1
7
56.8
metabolite measurement
1
56
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil-helix-coiled-coil-helix domain-containing protein 2
463422
Mouse
MGI:1261428
14004
Rat
RGD:1309819
316643
Dog
coiled-coil-helix-coiled-coil-helix domain containing 2
VGNC:54011
479702
Horse
coiled-coil-helix-coiled-coil-helix domain containing 2
100060727
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil-helix-coiled-coil-helix domain-containing protein 2
Mouse
Rat
Dog
coiled-coil-helix-coiled-coil-helix domain containing 2
Horse
coiled-coil-helix-coiled-coil-helix domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6H1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (157)
1 – 10 of 157
PRRC2A
Tbio
Novelty:  0.01493149
p_int:  0.999999507
p_ni:  4.89e-7
p_wrong:  3e-9
Data Source:  BioPlex
PHF10
Tbio
Family:  Epigenetic
Novelty:  0.05941323
p_int:  0.999998387
p_ni:  0.000001613
Data Source:  BioPlex
BNC2
Tbio
Family:  TF
Novelty:  0.0181682
p_int:  0.999997933
p_ni:  8.4e-8
p_wrong:  0.000001982
Data Source:  BioPlex
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.999997642
p_ni:  0.000002357
p_wrong:  1e-9
Data Source:  BioPlex
ZNF579
Tdark
Family:  TF
Novelty:  4.75515836
p_int:  0.999997229
p_ni:  0.00000277
Data Source:  BioPlex
RBM26
Tdark
Novelty:  0.26601554
p_int:  0.999994571
p_ni:  0.000005429
Data Source:  BioPlex
ZFP91
Tbio
Family:  TF
Novelty:  0.06937322
p_int:  0.999992843
p_ni:  0.000007157
Data Source:  BioPlex
FOXD4
Tbio
Family:  TF
Novelty:  0.11166611
p_int:  0.999985491
p_ni:  3.2e-8
p_wrong:  0.000014477
Score:  0.189
Data Source:  BioPlex,STRINGDB
BHLHA15
Tbio
Family:  TF
Novelty:  0.02721846
p_int:  0.999975632
p_ni:  5.6e-8
p_wrong:  0.000024312
Score:  0.165
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999972309
p_ni:  0.00002766
p_wrong:  3.1e-8
Score:  0.962
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  68.52

PubMed score by year
PubTator Score  42.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: