Tbio DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1

Protein Summary

Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q9Y6G9
• A2RRG7
• Q53HC8
• Q53HK7
• LIC1

Gene Name

• DYNC1LI1

Ensembl ID

• ENST00000273130
• ENSP00000273130
• ENSG00000144635

Symbol

• DNCLI1
• LIC1
• DLC-A
• DNCLI1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
molecular function	0.96
histone modification site profile	0.86
ligand (protein) perturbation	0.83
cellular component	0.82

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Cytoplasmic Dynein 1 Light Intermediate Chain 1

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Cytoplasmic Dynein 1 Light Intermediate Chain 1

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Cytoplasmic Dynein 1 Light Intermediate Chain 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.27   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.27   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0