You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
COMMD10
COMM domain-containing protein 10

Protein Summary
Description
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274458
  • ENSP00000274458
  • ENSG00000145781

Symbol
  • PTD002
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.88
transcription factor perturbation
0.84
virus perturbation
0.79
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (214)
1 – 10 of 214
COMMD2
Tdark
Novelty:  0.62195903
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  1
Score:  0.997
Data Source:  BioPlex,STRINGDB
COMMD3
Tbio
Novelty:  0.07399068
p_int:  1
Score:  0.996
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
COMMD4
Tbio
Novelty:  0.20453574
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
FAM45A
Tdark
Novelty:  0.94034891
p_int:  1
Score:  0.835
Data Source:  BioPlex,STRINGDB
COMMD5
Tbio
Novelty:  0.16163787
p_int:  0.999999758
p_ni:  2.42e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
VPS29
Tbio
Novelty:  0.01335106
p_int:  0.999999141
p_ni:  8.59e-7
Score:  0.843
Data Source:  BioPlex,STRINGDB
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
56.8
ankle brachial index
1
1
1
31.4
biological sex
1
1
1
21.5
neuroticism measurement
1
1
0
5.7
21.5
1
1
0
1.4
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
56.8
ankle brachial index
1
31.4
biological sex
1
21.5
neuroticism measurement
0
5.7
21.5
0
1.4
1.5
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COMM domain containing 10
VGNC:3955
462013
Macaque
COMM domain containing 10
698295
Mouse
MGI:1916706
69456
Rat
RGD:1303015
361323
Dog
COMM domain containing 10
VGNC:39492
474635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COMM domain containing 10
Macaque
COMM domain containing 10
Mouse
Rat
Dog
COMM domain containing 10
Publication Statistics
PubMed Score 5.95
PubMed score by year
PubTator Score 1.49
PubTator score by year