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Tbio
MRPL42
39S ribosomal protein L42, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000549561
  • ENSP00000449392
  • ENSG00000198015
  • ENST00000549982
  • ENSP00000449884
  • ENST00000552217
  • ENSP00000447547

Symbol
  • MRPL31
  • MRPS32
  • RPML31
  • L31MT
  • L42MT
  • S32MT
  • MRPL31
  • MRPS32
  • PTD007
  • RPML31
  • HSPC204
  • MRP-L31
  • MRP-L42
  • MRP-S32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
transcription factor binding site profile
0.7
disease perturbation
0.68
gene perturbation
0.65
histone modification site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
57.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L42
VGNC:5485
452126
Macaque
mitochondrial ribosomal protein L42
715676
Mouse
MGI:1333774
67270
Rat
RGD:1304915
299743
Horse
mitochondrial ribosomal protein L42
VGNC:20341
100629608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L42
Macaque
mitochondrial ribosomal protein L42
Mouse
Rat
Horse
mitochondrial ribosomal protein L42
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6G3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (150)
1 – 10 of 150
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.999999531
p_ni: 4.69e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.999992532
p_ni: 0.000007468
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999978961
p_ni: 0.000021039
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.999945325
p_ni: 0.000054675
Score: 0.967
Data Source: BioPlex,STRINGDB
MRPL51
Tdark
Novelty: 0.24304433
p_int: 0.999933844
p_ni: 0.000066155
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.999882736
p_ni: 0.000117264
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL21
Tdark
Novelty: 0.56552559
p_int: 0.999741383
p_ni: 0.000258617
Score: 0.996
Data Source: BioPlex,STRINGDB
GATC
Tbio
Family: Enzyme
Novelty: 0.62484697
p_int: 0.999466713
p_ni: 0.000533284
p_wrong: 2e-9
Data Source: BioPlex
MRPL45
Tdark
Novelty: 0.42464896
p_int: 0.999227365
p_ni: 0.000772635
Score: 0.993
Data Source: BioPlex,STRINGDB
MRPL40
Tbio
Novelty: 0.09916967
p_int: 0.999218769
p_ni: 0.000781231
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.02

PubMed score by year
PubTator Score  0.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer