Tbio MRPL42 39S ribosomal protein L42, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q9Y6G3
• Q6FID1
• Q96Q48
• Q9P0S1
• L42mt

Gene Name

• MRPL42

Ensembl ID

• ENST00000549561
• ENSP00000449392
• ENSG00000198015
• ENST00000549982
• ENSP00000449884
• ENST00000552217
• ENSP00000447547

Symbol

• MRPL31
• MRPS32
• RPML31
• L31MT
• L42MT
• S32MT
• MRPL31
• MRPS32
• PTD007
• RPML31
• HSPC204
• MRP-L31
• MRP-L42
• MRP-S32

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
transcription factor binding site profile	0.7
disease perturbation	0.68
gene perturbation	0.65
histone modification site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0