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Tbio
TMEM14A
Transmembrane protein 14A

Protein Summary
Description
Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211314
  • ENSP00000211314
  • ENSG00000096092

Symbol
  • C6orf73
  • PTD011
  • C6orf73
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor perturbation
0.74
kinase perturbation
0.71
transcription factor binding site profile
0.6
histone modification site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (33)
1 – 10 of 33
TMEM141
Tdark
Novelty:  0.62732191
Score:  0.81
Data Source:  STRINGDB
HIGD1B
Tdark
Novelty:  0.30493093
Score:  0.787
Data Source:  STRINGDB
TMEM14EP
Tdark
Novelty:  1.69354839
Score:  0.701
Data Source:  STRINGDB
SLC35G2
Tdark
Family:  Transporter
Novelty:  0.57896683
Score:  0.691
Data Source:  STRINGDB
DKK4
Tbio
Novelty:  0.02793673
Score:  0.683
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.648
Data Source:  STRINGDB
TRAM2
Tbio
Novelty:  0.08830467
Score:  0.644
Data Source:  STRINGDB
ANAPC2
Tbio
Family:  Enzyme
Novelty:  0.19812984
Score:  0.637
Data Source:  STRINGDB
GPM6A
Tbio
Novelty:  0.04123799
Score:  0.608
Data Source:  STRINGDB
RTKN
Tbio
Novelty:  0.01044337
Score:  0.588
Data Source:  STRINGDB
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
3
4
85.3
red blood cell distribution width
2
2
2
82.4
low density lipoprotein cholesterol measurement
3
2
3
75.4
mean corpuscular hemoglobin concentration
1
1
1
73.9
glomerular filtration rate
3
2
3
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
85.3
red blood cell distribution width
2
82.4
low density lipoprotein cholesterol measurement
3
75.4
mean corpuscular hemoglobin concentration
1
73.9
glomerular filtration rate
3
68.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 14A
VGNC:3749
100611130
Mouse
MGI:1922962
75712
Rat
RGD:9417885
103693210
Horse
transmembrane protein 14A
VGNC:24205
100630848
Cow
transmembrane protein 14A
VGNC:35979
510383
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 14A
Mouse
Rat
Horse
transmembrane protein 14A
Cow
transmembrane protein 14A
Publication Statistics
PubMed Score 5.89
PubMed score by year
PubTator Score 1.74
PubTator score by year