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Tbio
WNT6
Protein Wnt-6

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233948
  • ENSP00000233948
  • ENSG00000115596
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
biological process
0.72
cell type or tissue
0.72
PubMedID
0.72
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.38   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.38   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
16
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98960
22420
Rat
RGD:1304559
316526
Dog
Wnt family member 6
VGNC:48427
488527
Horse
Wnt family member 6 [Source:HGNC Symbol;Acc:HGNC:12785]
Cow
Wnt family member 6
VGNC:36962
505075
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Wnt family member 6
Horse
Wnt family member 6 [Source:HGNC Symbol;Acc:HGNC:12785]
Cow
Wnt family member 6
Pathways (58)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (109)
1 – 10 of 109
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.975
Data Source: STRINGDB
PORCN
Tchem
Family: Enzyme
Novelty: 0.00834643
Score: 0.974
Data Source: STRINGDB
FZD4
Tchem
Family: GPCR
Novelty: 0.00577957
Score: 0.972
Data Source: STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.969
Data Source: STRINGDB
FZD9
Tbio
Family: GPCR
Novelty: 0.01414546
Score: 0.967
Data Source: STRINGDB
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
Score: 0.966
Data Source: STRINGDB
FZD5
Tbio
Family: GPCR
Novelty: 0.01673829
Score: 0.966
Data Source: STRINGDB
FZD8
Tbio
Family: GPCR
Novelty: 0.01613553
Score: 0.965
Data Source: STRINGDB
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
Score: 0.964
Data Source: STRINGDB
FZD6
Tbio
Family: GPCR
Novelty: 0.01425136
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  101.38

PubMed score by year
PubTator Score  28.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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