Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosom ...more
- ENST00000233948
- ENSP00000233948
- ENSG00000115596
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.79 | ||
biological process | 0.72 | ||
cell type or tissue | 0.72 | ||
PubMedID | 0.72 | ||
transcription factor | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.43 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 233 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.43 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 233 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (109)
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (58)
Reactome (6)
KEGG (13)
PathwayCommons (29)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Reactome | Signaling by WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Signaling by WNT | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (1)
Components (9)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 5 | 3 | 6 | 94.2 | |||||
balding measurement | 2 | 3 | 3 | 94.1 | |||||
high density lipoprotein cholesterol measurement | 4 | 2 | 5 | 87.2 | |||||
2 | 2 | 1 | 1.3 | 83.6 | |||||
1 | 3 | 3 | 82.9 | ||||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 6 | 94.2 | |||||
balding measurement | 3 | 94.1 | |||||
high density lipoprotein cholesterol measurement | 5 | 87.2 | |||||
1 | 1.3 | 83.6 | |||||
3 | 82.9 | ||||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:98960 | 22420 | ||||||
Rat | RGD:1304559 | 316526 | ||||||
Dog | Wnt family member 6 | VGNC:48427 | 488527 | |||||
Horse | Wnt family member 6 [Source:HGNC Symbol;Acc:HGNC:12785] | |||||||
Cow | Wnt family member 6 | VGNC:36962 | 505075 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 6 | |||||
Horse | Wnt family member 6 [Source:HGNC Symbol;Acc:HGNC:12785] | |||||
Cow | Wnt family member 6 | |||||
Publication Statistics
PubMed Score 103.43
PubMed score by year
PubTator Score 28.29
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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