Protein Classes
Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosom ...more
- ENST00000233948
- ENSP00000233948
- ENSG00000115596
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.79 | ||
biological process | 0.72 | ||
cell type or tissue | 0.72 | ||
PubMedID | 0.72 | ||
transcription factor | 0.68 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.38 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 233 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.38 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 233 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 16 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 16 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:98960 | 22420 | ||||||
Rat | RGD:1304559 | 316526 | ||||||
Dog | Wnt family member 6 | VGNC:48427 | 488527 | |||||
Horse | Wnt family member 6 [Source:HGNC Symbol;Acc:HGNC:12785] | |||||||
Cow | Wnt family member 6 | VGNC:36962 | 505075 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 6 | |||||
Horse | Wnt family member 6 [Source:HGNC Symbol;Acc:HGNC:12785] | |||||
Cow | Wnt family member 6 | |||||
Pathways (58)
Reactome (6)
KEGG (13)
PathwayCommons (29)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Reactome | Signaling by WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Signaling by WNT | ||||
Gene Ontology Terms (23)
Functions (1)
Components (9)
Processes (13)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (109)
1 – 10 of 109
FZD1
Family: GPCR
Novelty: 0.01097201
Score: 0.975
Data Source: STRINGDB
PORCN
Family: Enzyme
Novelty: 0.00834643
Score: 0.974
Data Source: STRINGDB
FZD4
Family: GPCR
Novelty: 0.00577957
Score: 0.972
Data Source: STRINGDB
FZD2
Family: GPCR
Novelty: 0.00774893
Score: 0.969
Data Source: STRINGDB
FZD9
Family: GPCR
Novelty: 0.01414546
Score: 0.967
Data Source: STRINGDB
FZD7
Family: GPCR
Novelty: 0.00916448
Score: 0.966
Data Source: STRINGDB
FZD5
Family: GPCR
Novelty: 0.01673829
Score: 0.966
Data Source: STRINGDB
FZD8
Family: GPCR
Novelty: 0.01613553
Score: 0.965
Data Source: STRINGDB
FZD3
Family: GPCR
Novelty: 0.00964507
Score: 0.964
Data Source: STRINGDB
FZD6
Family: GPCR
Novelty: 0.01425136
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score 101.38
PubMed score by year
PubTator Score 28.29
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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