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Tbio
MRVI1
Protein MRVI1

Protein Summary
Description
Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423302
  • ENSP00000412130
  • ENSG00000072952
  • ENST00000424001
  • ENSP00000401205
  • ENST00000531107
  • ENSP00000432436
  • ENST00000534266
  • ENSP00000433296
  • ENST00000541483
  • ENSP00000437784
  • ENST00000547195
  • ENSP00000448278
  • ENST00000558540
  • ENSP00000453013

Symbol
  • IRAG
  • JAW1L
  • IRAG
  • JAW1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.75
transcription factor
0.73
cellular component
0.63
trait
0.61
cell type or tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.44   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.44   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
96.6
hemoglobin measurement
1
2
2
80
hematocrit
1
2
2
77.2
reticulocyte count
2
1
2
71.6
platelet count
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
96.6
hemoglobin measurement
2
80
hematocrit
2
77.2
reticulocyte count
2
71.6
platelet count
1
68.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
murine retrovirus integration site 1 homolog
451025
Macaque
murine retrovirus integration site 1 homolog
702830
Mouse
MGI:1338023
17540
Rat
RGD:1309828
308899
Dog
murine retrovirus integration site 1 homolog
100855453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
murine retrovirus integration site 1 homolog
Macaque
murine retrovirus integration site 1 homolog
Mouse
Rat
Dog
murine retrovirus integration site 1 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6F6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Reactome
cGMP effects
Name
Explore in Pharos
Explore in Source
Hemostasis
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
cGMP effects
Gene Ontology Terms (5)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (41)
1 – 10 of 41
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
p_int:  0.999999849
p_ni:  1.51e-7
Score:  0.851
Data Source:  BioPlex,STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
p_int:  0.99999948
p_ni:  5.2e-7
Score:  0.925
Data Source:  BioPlex,STRINGDB
ITPRID2
Tbio
Novelty:  0.07923791
p_int:  0.999984672
p_ni:  0.000015326
p_wrong:  2e-9
Data Source:  BioPlex
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.957893698
p_ni:  0.040346752
p_wrong:  0.00175955
Data Source:  BioPlex
BOK
Tbio
Novelty:  0.0154001
p_int:  0.92229819
p_ni:  2.58e-7
p_wrong:  0.077701552
Data Source:  BioPlex
USP25
Tchem
Family:  Enzyme
Novelty:  0.03671706
p_int:  0.877759595
p_ni:  0.122239702
p_wrong:  7.03e-7
Data Source:  BioPlex
UFL1
Tbio
Family:  Enzyme
Novelty:  0.02941148
p_int:  0.862782389
p_ni:  0.137217611
Data Source:  BioPlex
DDRGK1
Tbio
Novelty:  0.10774064
p_int:  0.758176122
p_ni:  0.241823286
p_wrong:  5.92e-7
Data Source:  BioPlex
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.994
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  33.44

PubMed score by year
PubTator Score  14.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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