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Tclin
PARP3
Poly [ADP-ribose] polymerase 3

Protein Summary
Description
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternativel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398755
  • ENSP00000381740
  • ENSG00000041880
  • ENST00000417220
  • ENSP00000395951
  • ENST00000431474
  • ENSP00000401511

Symbol
  • ADPRT3
  • ADPRTL3
  • IRT1
  • ARTD3
  • ADPRT3
  • ADPRTL2
  • ADPRTL3
  • PADPRT-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.88
histone modification site profile
0.8
disease perturbation
0.74
transcription factor binding site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.45   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.45   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (65)
PAK1
Tchem
Family:  Kinase
Novelty:  0.00411227
p_int:  0.966078195
p_ni:  0.033921296
p_wrong:  5.1e-7
Data Source:  BioPlex
RALGAPB
Tbio
Family:  Enzyme
Novelty:  0.31941838
p_int:  0.957466616
p_ni:  0.042533379
p_wrong:  5e-9
Data Source:  BioPlex
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
p_int:  0.897694894
p_ni:  0.006869564
p_wrong:  0.095435542
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.851545455
p_ni:  0.148454545
Data Source:  BioPlex
DMWD
Tbio
Novelty:  0.04096001
p_int:  0.848331094
p_ni:  0.146984294
p_wrong:  0.004684612
Data Source:  BioPlex
PARG
Tchem
Family:  Enzyme
Novelty:  0.00424731
Score:  0.861
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.84
Data Source:  STRINGDB
PARP6
Tchem
Family:  Enzyme
Novelty:  0.10074447
Score:  0.834
Data Source:  STRINGDB
CASP7
Tchem
Family:  Enzyme
Novelty:  0.00126224
Score:  0.831
Data Source:  STRINGDB
CASP9
Tchem
Family:  Enzyme
Novelty:  0.00023687
Score:  0.823
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Base excision repair
KEGG
Necroptosis
KEGG
Apoptosis
Name
Explore in Pharos
Explore in Source
Base excision repair
Necroptosis
Apoptosis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
69.4
macrophage inflammatory protein 1b measurement
1
1
1
33.1
urate measurement
1
1
1
12.2
high density lipoprotein cholesterol measurement
1
1
1
10.6
apolipoprotein A 1 measurement
1
1
1
8.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
69.4
macrophage inflammatory protein 1b measurement
1
33.1
urate measurement
1
12.2
high density lipoprotein cholesterol measurement
1
10.6
apolipoprotein A 1 measurement
1
8.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 3
VGNC:2498
460409
Macaque
poly(ADP-ribose) polymerase family member 3
699294
Mouse
MGI:1891258
235587
Rat
RGD:1305189
300985
Dog
poly(ADP-ribose) polymerase family member 3
484745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 3
Macaque
poly(ADP-ribose) polymerase family member 3
Mouse
Rat
Dog
poly(ADP-ribose) polymerase family member 3
Publication Statistics
PubMed Score 57.45
PubMed score by year
PubTator Score 38.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title