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Tbio
SIRT4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

Protein Summary
Description
Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000202967
  • ENSP00000202967
  • ENSG00000089163

Symbol
  • SIR2L4
  • SIR2L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
biological process
0.82
kinase perturbation
0.76
protein domain
0.73
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.23   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.23   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.89326463
p_ni:  0.10673537
Score:  0.298
Data Source:  BioPlex,STRINGDB
SNX3
Tbio
Novelty:  0.02703152
p_int:  0.869244697
p_ni:  0.125773916
p_wrong:  0.004981387
Score:  0.28
Data Source:  BioPlex,STRINGDB
GLUD1
Tbio
Family:  Enzyme
Novelty:  0.00301109
Score:  0.961
Data Source:  Reactome,STRINGDB
GLUD2
Tbio
Family:  Enzyme
Novelty:  0.01470266
Score:  0.933
Data Source:  STRINGDB
HDAC11
Tclin
Family:  Epigenetic
Novelty:  0.01015211
Score:  0.884
Data Source:  STRINGDB
FOXO3
Tbio
Family:  TF
Novelty:  0.00074316
Score:  0.839
Data Source:  STRINGDB
HDAC6
Tclin
Family:  Epigenetic
Novelty:  0.00122232
Score:  0.821
Data Source:  STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
Score:  0.819
Data Source:  STRINGDB
HDAC4
Tclin
Family:  Epigenetic
Novelty:  0.00217749
Score:  0.809
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.805
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Mitochondrial biogenesis (R-HSA-1592230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
8
8
93.4
Left ventricular mass to end-diastolic volume ratio
1
1
1
40.7
mean corpuscular volume
1
1
1
39.6
platelet count
1
1
1
31.4
appendicular lean mass
1
2
2
29.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
8
93.4
Left ventricular mass to end-diastolic volume ratio
1
40.7
mean corpuscular volume
1
39.6
platelet count
1
31.4
appendicular lean mass
2
29.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sirtuin 4
VGNC:13444
742235
Mouse
MGI:1922637
75387
Rat
RGD:1310413
304539
Dog
sirtuin 4
VGNC:46185
477507
Horse
sirtuin 4
VGNC:22989
100053520
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sirtuin 4
Mouse
Rat
Dog
sirtuin 4
Horse
sirtuin 4
Publication Statistics
PubMed Score 399.23
PubMed score by year
PubTator Score 74.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title