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Tbio
BZW2
Basic leucine zipper and W2 domain-containing protein 2

Protein Summary
Description
May be involved in neuronal differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258761
  • ENSP00000258761
  • ENSG00000136261
  • ENST00000433922
  • ENSP00000397249

Symbol
  • MST017
  • HSPC028
  • MSTP017
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.97
kinase perturbation
0.95
histone modification site profile
0.85
transcription factor binding site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.45   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.45   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
88.8
reticulocyte count
7
2
13
74.6
red blood cell distribution width
2
1
2
67.8
reticulocyte measurement
3
2
6
66.5
mean corpuscular hemoglobin concentration
1
1
1
62.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
88.8
reticulocyte count
13
74.6
red blood cell distribution width
2
67.8
reticulocyte measurement
6
66.5
mean corpuscular hemoglobin concentration
1
62.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper and W2 domains 2
VGNC:4281
463276
Macaque
basic leucine zipper and W2 domains 2
714627
Mouse
MGI:1914162
66912
Rat
RGD:621507
171439
Dog
basic leucine zipper and W2 domains 2
VGNC:38572
100856737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper and W2 domains 2
Macaque
basic leucine zipper and W2 domains 2
Mouse
Rat
Dog
basic leucine zipper and W2 domains 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6E2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (54)
1 – 10 of 54
MUL1
Tbio
Family: Enzyme
Novelty: 0.00841786
p_int: 0.999982863
p_ni: 0.000017137
Data Source: BioPlex
EXOG
Tbio
Family: Enzyme
Novelty: 0.03588463
p_int: 0.99993353
p_ni: 0.00006647
Data Source: BioPlex
BZW1
Tbio
Novelty: 0.11677238
p_int: 0.999906101
p_ni: 0.000093899
Score: 0.826
Data Source: BioPlex,STRINGDB
NT5C3A
Tbio
Family: Enzyme
Novelty: 0.01939545
p_int: 0.999187747
p_ni: 0.000812253
Data Source: BioPlex
CANT1
Tbio
Family: Enzyme
Novelty: 0.02640333
p_int: 0.998873674
p_ni: 0.001126156
p_wrong: 1.7e-7
Data Source: BioPlex
ENDOD1
Tdark
Family: Enzyme
Novelty: 0.26430864
p_int: 0.997981729
p_ni: 0.001479141
p_wrong: 0.00053913
Score: 0.207
Data Source: BioPlex,STRINGDB
TMEM43
Tbio
Novelty: 0.03549545
p_int: 0.995934501
p_ni: 0.004065499
Score: 0.313
Data Source: BioPlex,STRINGDB
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.992734006
p_ni: 0.007265994
Data Source: BioPlex
ZFPL1
Tbio
Novelty: 0.1829181
p_int: 0.989809891
p_ni: 0.004837987
p_wrong: 0.005352122
Data Source: BioPlex
SCCPDH
Tbio
Family: Enzyme
Novelty: 0.06603568
p_int: 0.987601171
p_ni: 0.012396554
p_wrong: 0.000002274
Data Source: BioPlex
Publication Statistics
PubMed Score  7.45

PubMed score by year
PubTator Score  1.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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