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Tchem
STK24
Serine/threonine-protein kinase 24

Protein Summary
Description
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376547
  • ENSP00000365730
  • ENSG00000102572
  • ENST00000539966
  • ENSP00000442539

Symbol
  • MST3
  • STK3
  • MST3
  • STK3
  • MST3B
  • STE20
  • HEL-S-95
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
0.97
molecular function
0.97
transcription factor perturbation
0.96
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.18   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.18   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
95.7
unipolar depression
1
1
0
1
95
self reported educational attainment
3
1
3
93.4
neuroticism measurement
3
3
3
5.5
92.8
wellbeing measurement
3
2
3
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
95.7
unipolar depression
0
1
95
self reported educational attainment
3
93.4
neuroticism measurement
3
5.5
92.8
wellbeing measurement
3
90.7
Protein Data Bank (28)
1 – 5 of 28
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Programmed Cell Death
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (94)
1 – 10 of 94
PDCD10
Tbio
Novelty: 0.00683934
p_int: 1
Score: 0.987
Data Source: BioPlex,STRINGDB
STK25
Tchem
Family: Kinase
Novelty: 0.03229688
p_int: 0.999999999
p_ni: 1e-9
Score: 0.864
Data Source: BioPlex,STRINGDB
PROSER2
Tdark
Novelty: 0.56334611
p_int: 0.999999416
p_ni: 5.84e-7
Score: 0.768
Data Source: BioPlex,STRINGDB
C4orf19
Tdark
Novelty: 2.1863624
p_int: 0.999999214
p_ni: 7.86e-7
Score: 0.864
Data Source: BioPlex,STRINGDB
MAGIX
Tdark
Novelty: 0.38577176
p_int: 0.999669767
p_ni: 0.000330233
Score: 0.167
Data Source: BioPlex,STRINGDB
ATP6V1C2
Tbio
Family: Enzyme
Novelty: 0.07583427
p_int: 0.979810169
p_ni: 0.020189796
p_wrong: 3.6e-8
Score: 0.571
Data Source: BioPlex,STRINGDB
CAB39
Tbio
Novelty: 0.01592402
Score: 0.983
Data Source: STRINGDB
STRN
Tbio
Novelty: 0.01025814
Score: 0.972
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.948
Data Source: Reactome,STRINGDB
STRIP1
Tbio
Novelty: 0.13320106
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  164.18

PubMed score by year
PubTator Score  98.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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