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Tbio
MAD1L1
Mitotic spindle assembly checkpoint protein MAD1

Protein Summary
Description
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265854
  • ENSP00000265854
  • ENSG00000002822
  • ENST00000399654
  • ENSP00000382562
  • ENST00000402746
  • ENSP00000384155
  • ENST00000406869
  • ENSP00000385334

Symbol
  • MAD1
  • TXBP181
  • MAD1
  • PIG9
  • TP53I9
  • TXBP181
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
interacting protein
0.9
kinase perturbation
0.88
transcription factor binding site profile
0.86
cellular component
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.98   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.98   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
3
3
1
3.3
98.9
self reported educational attainment
3
5
5
98.6
9
7
1
1.1
97.8
smoking status measurement
2
2
2
97.8
mathematical ability
4
5
5
97.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
3.3
98.9
self reported educational attainment
5
98.6
1
1.1
97.8
smoking status measurement
2
97.8
mathematical ability
5
97.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitotic arrest deficient 1 like 1
VGNC:10052
463223
Macaque
mitotic arrest deficient 1 like 1
712947
Mouse
MGI:1341857
17120
Rat
RGD:1596881
680006
Dog
mitotic arrest deficient 1 like 1
VGNC:42914
609673
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitotic arrest deficient 1 like 1
Macaque
mitotic arrest deficient 1 like 1
Mouse
Rat
Dog
mitotic arrest deficient 1 like 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6D9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (173)
1 – 10 of 173
FAM9B
Tdark
Novelty: 0.39508009
p_int: 0.999998902
p_ni: 0.000001098
Data Source: BioPlex
BAG5
Tbio
Novelty: 0.0318404
p_int: 0.999980124
p_ni: 0.000019875
Score: 0.277
Data Source: BioPlex,STRINGDB
CAVIN1
Tbio
Family: Enzyme
Novelty: 0.00780634
p_int: 0.999934807
p_ni: 0.000065193
Score: 0.239
Data Source: BioPlex,STRINGDB
ZADH2
Tdark
Family: Enzyme
Novelty: 0.11800677
p_int: 0.999920552
p_ni: 0.000079445
p_wrong: 3e-9
Score: 0.191
Data Source: BioPlex,STRINGDB
BMP1
Tchem
Novelty: 0.00299518
p_int: 0.998557545
p_ni: 0.00144243
p_wrong: 2.5e-8
Data Source: BioPlex
CLEC11A
Tbio
Novelty: 0.03060601
p_int: 0.997784179
p_ni: 0.002215821
Data Source: BioPlex
TPM1
Tbio
Novelty: 0.00261206
p_int: 0.996832336
p_ni: 0.003167664
Score: 0.332
Data Source: BioPlex,STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
p_int: 0.99351065
p_ni: 0.00648935
Score: 0.235
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.98399949
p_ni: 0.01600051
Data Source: BioPlex
ASB7
Tdark
Novelty: 0.21883348
p_int: 0.898289292
p_ni: 0.101710708
Score: 0.159
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.98

PubMed score by year
PubTator Score  54.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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