Tbio MAD1L1 Mitotic spindle assembly checkpoint protein MAD1

Protein Summary

Description

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• Q9Y6D9
• B3KR41
• Q13312
• Q75MI0
• Q86UM4
• Q9UNH0

Gene Name

• MAD1L1

Ensembl ID

• ENST00000265854
• ENSP00000265854
• ENSG00000002822
• ENST00000399654
• ENSP00000382562
• ENST00000402746
• ENSP00000384155
• ENST00000406869
• ENSP00000385334

Symbol

• MAD1
• TXBP181
• MAD1
• PIG9
• TP53I9
• TXBP181

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
interacting protein	0.9
kinase perturbation	0.88
transcription factor binding site profile	0.86
cellular component	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.48   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 371   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.48   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0