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Tbio
SELENOK
Selenoprotein K

Protein Summary
Description
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588). The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000495461
  • ENSP00000418813
  • ENSG00000113811

Symbol
  • SELK
  • SELK
  • HSPC030
  • HSPC297
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.39   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.39   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 17 receptor B measurement
1
1
1
70.2
refractive error measurement
2
2
1
6.5
58.9
Myopia
1
1
0
6.5
46.5
age at onset
1
1
0
6.5
46.5
smoking status measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 17 receptor B measurement
1
70.2
refractive error measurement
1
6.5
58.9
Myopia
0
6.5
46.5
age at onset
0
6.5
46.5
smoking status measurement
1
38.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selenoprotein K
VGNC:14631
460454
Mouse
MGI:1931466
80795
Rat
RGD:1303129
290549
Horse
selenoprotein K
100316857
Cow
selenoprotein K
615114
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selenoprotein K
Mouse
Rat
Horse
selenoprotein K
Cow
selenoprotein K
Pathways (11)
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
IL1 and megakaryocytes in obesity
WikiPathways
Blood Clotting Cascade
Name
Explore in Pharos
Explore in Source
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Micronutrient Network
IL1 and megakaryocytes in obesity
Blood Clotting Cascade
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (52)
1 – 10 of 52
SELENOS
Tbio
Novelty:  0.01108715
Score:  0.966
Data Source:  STRINGDB
SELENOO
Tdark
Novelty:  0.02959704
Score:  0.946
Data Source:  STRINGDB
SELENOT
Tbio
Novelty:  0.02480242
Score:  0.917
Data Source:  STRINGDB
SELENOI
Tbio
Family:  Enzyme
Novelty:  0.00809865
Score:  0.896
Data Source:  STRINGDB
MSRB1
Tbio
Family:  Enzyme
Novelty:  0.01677161
Score:  0.877
Data Source:  STRINGDB
SELENON
Tbio
Novelty:  0.01018
Score:  0.875
Data Source:  STRINGDB
SELENOP
Tbio
Novelty:  0.00194637
Score:  0.854
Data Source:  STRINGDB
SELENOW
Tbio
Novelty:  0.00967095
Score:  0.849
Data Source:  STRINGDB
SELENOH
Tbio
Novelty:  0.02421467
Score:  0.817
Data Source:  STRINGDB
SELENOV
Tdark
Novelty:  0.05279914
Score:  0.805
Data Source:  STRINGDB
Publication Statistics
PubMed Score  57.39

PubMed score by year
PubTator Score  24.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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