Protein Summary
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588). The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also ...more
- ENST00000495461
- ENSP00000418813
- ENSG00000113811
- SELK
- SELK
- HSPC030
- HSPC297
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.39 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.39 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (52)
Nearest Tclin Targets
Pathways (11)
WikiPathways (11)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Selenium Micronutrient Network | ||||
WikiPathways | Selenium Micronutrient Network | ||||
WikiPathways | Selenium Micronutrient Network | ||||
WikiPathways | IL1 and megakaryocytes in obesity | ||||
WikiPathways | Blood Clotting Cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Selenium Micronutrient Network | ||||
Selenium Micronutrient Network | ||||
Selenium Micronutrient Network | ||||
IL1 and megakaryocytes in obesity | ||||
Blood Clotting Cascade | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (1)
Components (5)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
interleukin 17 receptor B measurement | 1 | 1 | 1 | 70.2 | |||||
refractive error measurement | 2 | 2 | 1 | 6.5 | 58.9 | ||||
Myopia | 1 | 1 | 0 | 6.5 | 46.5 | ||||
age at onset | 1 | 1 | 0 | 6.5 | 46.5 | ||||
smoking status measurement | 1 | 1 | 1 | 38.8 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
interleukin 17 receptor B measurement | 1 | 70.2 | |||||
refractive error measurement | 1 | 6.5 | 58.9 | ||||
Myopia | 0 | 6.5 | 46.5 | ||||
age at onset | 0 | 6.5 | 46.5 | ||||
smoking status measurement | 1 | 38.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | selenoprotein K | VGNC:14631 | 460454 | |||||
Mouse | MGI:1931466 | 80795 | ||||||
Rat | RGD:1303129 | 290549 | ||||||
Horse | selenoprotein K | 100316857 | ||||||
Cow | selenoprotein K | 615114 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | selenoprotein K | |||||
Mouse | ||||||
Rat | ||||||
Horse | selenoprotein K | |||||
Cow | selenoprotein K | |||||
Publication Statistics
PubMed Score 57.39
PubMed score by year
PubTator Score 24.07
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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