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Tbio
MTCH2
Mitochondrial carrier homolog 2

Protein Summary
Description
The substrate transported is not yet known. Induces mitochondrial depolarization. This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302503
  • ENSP00000303222
  • ENSG00000109919
  • ENST00000643223
  • ENSP00000495027
  • ENSG00000285121

Symbol
  • MIMP
  • MIMP
  • HSPC032
  • SLC25A50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.98
disease perturbation
0.95
transcription factor binding site profile
0.88
histone modification site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.23   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.23   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
12
3
17
99
self reported educational attainment
2
2
2
93.4
cognitive function measurement
2
1
2
74.1
worry measurement
1
1
1
57.6
visceral adipose tissue measurement
1
1
1
48.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
99
self reported educational attainment
2
93.4
cognitive function measurement
2
74.1
worry measurement
1
57.6
visceral adipose tissue measurement
1
48.7
Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (159)
1 – 10 of 159
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.999801396
p_ni: 0.000198605
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.998174018
p_ni: 0.001825982
Data Source: BioPlex
SLC7A1
Tbio
Family: Transporter
Novelty: 0.00197313
p_int: 0.998126788
p_ni: 0.001873191
p_wrong: 2.1e-8
Data Source: BioPlex
IMPDH1
Tclin
Family: Enzyme
Novelty: 0.00758575
p_int: 0.997370295
p_ni: 0.002629705
Data Source: BioPlex
TSPAN1
Tbio
Novelty: 0.01547855
p_int: 0.996381292
p_ni: 0.003618708
Data Source: BioPlex
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01137558
p_int: 0.995849702
p_ni: 0.004143709
p_wrong: 0.000006589
Data Source: BioPlex
CD44
Tbio
Novelty: 0.00011321
p_int: 0.994030965
p_ni: 0.005969035
Data Source: BioPlex
RFX3
Tbio
Family: TF
Novelty: 0.04646733
p_int: 0.991130875
p_ni: 0.008869122
p_wrong: 3e-9
Data Source: BioPlex
TGFA
Tbio
Novelty: 0.00216159
p_int: 0.990236872
p_ni: 0.009763128
Data Source: BioPlex
PVR
Tbio
Novelty: 0.00215811
p_int: 0.983644453
p_ni: 0.016355545
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  57.23

PubMed score by year
PubTator Score  18.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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