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Tbio
PTCH2
Protein patched homolog 2

Protein Summary
Description
May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372192
  • ENSP00000361266
  • ENSG00000117425
  • ENST00000447098
  • ENSP00000389703

Symbol
  • PTC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.82
histone modification site profile
0.77
PubMedID
0.61
cell type or tissue
0.6
phenotype
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.99   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.99   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
0
7
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
0
7
54.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patched 2
VGNC:1477
469185
Mouse
MGI:1095405
19207
Dog
patched 2
VGNC:45133
482519
Horse
patched 2
VGNC:21980
100052702
Cow
patched 2
VGNC:33492
507948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patched 2
Mouse
Dog
patched 2
Horse
patched 2
Cow
patched 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6C5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Reactome
GPCR ligand binding
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GLI proteins bind promoters of Hh responsive genes to promote transcription
GPCR ligand binding
Hedgehog 'on' state
Signal Transduction
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (58)
1 – 10 of 58
SHH
Tchem
Novelty:  0.00028347
Score:  0.992
Data Source:  STRINGDB
IHH
Tbio
Novelty:  0.00174847
Score:  0.99
Data Source:  STRINGDB
DHH
Tbio
Novelty:  0.00329784
Score:  0.99
Data Source:  STRINGDB
SMO
Tclin
Family:  GPCR
Novelty:  0.03235855
Score:  0.986
Data Source:  STRINGDB
GLI1
Tchem
Family:  TF
Novelty:  0.00077281
Score:  0.982
Data Source:  STRINGDB
GLI2
Tchem
Family:  TF
Novelty:  0.00229126
Score:  0.967
Data Source:  STRINGDB
GLI3
Tbio
Family:  TF
Novelty:  0.00051217
Score:  0.965
Data Source:  STRINGDB
PTCH1
Tbio
Novelty:  0.00077635
Score:  0.906
Data Source:  STRINGDB
CDON
Tbio
Novelty:  0.00447262
Score:  0.897
Data Source:  STRINGDB
GAS1
Tbio
Novelty:  0.00423304
Score:  0.897
Data Source:  STRINGDB
Publication Statistics
PubMed Score  89.99

PubMed score by year
PubTator Score  59.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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