Protein Summary
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. [provided by RefSeq, Sep 2009]
- ENST00000380320
- ENSP00000369677
- ENSG00000138080
- EMI
- EMI
- gp115
- EMILIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.69 | ||
tissue sample | 0.64 | ||
protein domain | 0.58 | ||
cell type or tissue | 0.57 | ||
cell line | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.66 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.66 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
TAB2
Family: Enzyme
Novelty: 0.00635786
p_int: 0.99999994
p_ni: 3.7e-8
p_wrong: 2.3e-8
Data Source: BioPlex
TAB3
Family: Enzyme
Novelty: 0.01768638
p_int: 0.999999929
p_ni: 3.2e-8
p_wrong: 3.9e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
MAP3K7
Family: Kinase
Novelty: 0.00540177
p_int: 0.999998764
p_ni: 0.000001236
Score: 0.168
Data Source: BioPlex,STRINGDB
TAB1
Family: Kinase
Novelty: 0.00721424
p_int: 0.999981858
p_ni: 0.000018142
Data Source: BioPlex
DDHD2
Family: Enzyme
Novelty: 0.04306798
p_int: 0.999976624
p_ni: 0.000023035
p_wrong: 3.41e-7
Data Source: BioPlex
METTL15
Family: Enzyme
Novelty: 0.4575663
p_int: 0.999821434
p_ni: 0.000178564
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (3)
Components (8)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 3 | 8 | 8 | 92.5 | |||||
neutrophil count | 1 | 1 | 1 | 72.9 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 68.8 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 67.1 | |||||
IGF-1 measurement | 1 | 2 | 2 | 60.9 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 8 | 92.5 | |||||
neutrophil count | 1 | 72.9 | |||||
neutrophil percentage of leukocytes | 1 | 68.8 | |||||
lymphocyte percentage of leukocytes | 1 | 67.1 | |||||
IGF-1 measurement | 2 | 60.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | elastin microfibril interfacer 1 | VGNC:240 | 459093 | |||||
Macaque | elastin microfibril interfacer 1 | 698204 | ||||||
Mouse | MGI:1926189 | 100952 | ||||||
Rat | RGD:1311209 | 298845 | ||||||
Dog | elastin microfibril interfacer 1 | VGNC:40343 | 475696 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | elastin microfibril interfacer 1 | |||||
Macaque | elastin microfibril interfacer 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | elastin microfibril interfacer 1 | |||||
Publication Statistics
PubMed Score 40.66
PubMed score by year
PubTator Score 33.44
PubTator score by year
Related Publications
Text Mined References (46)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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