SAR1B
GTP-binding protein SAR1b
Protein Summary
Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
- ENST00000402673
- ENSP00000385432
- ENSG00000152700
- ENST00000439578
- ENSP00000404997
- SARA2
- SARB
- ANDD
- CMRD
- GTBPB
- SARA2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
kinase perturbation | 0.93 | ||
molecular function | 0.93 | ||
histone modification site profile | 0.83 | ||
cell type or tissue | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.87 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 248 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.87 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 248 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0