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Tbio
SPCS1
Signal peptidase complex subunit 1

Protein Classes
Protein Summary
Description
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000602728
  • ENSP00000473265
  • ENSG00000114902

Symbol
  • SPC12
  • SPC1
  • SPC12
  • HSPC033
  • YJR010C-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.91
transcription factor perturbation
0.91
kinase perturbation
0.88
cell type or tissue
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
1
2
95.8
intelligence
2
1
1
6.2
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
95.8
intelligence
1
6.2
75.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal peptidase complex subunit 1
VGNC:2570
746519
Macaque
signal peptidase complex subunit 1
696426
Rat
RGD:1309125
290555
Dog
signal peptidase complex subunit 1
476592
Pig
signal peptidase complex subunit 1
100135675
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal peptidase complex subunit 1
Macaque
signal peptidase complex subunit 1
Rat
Dog
signal peptidase complex subunit 1
Pig
signal peptidase complex subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6A9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Incretin synthesis, secretion, and inactivation (R-HSA-400508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Incretin synthesis, secretion, and inactivation
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Synthesis, secretion, and deacylation of Ghrelin
Name
Explore in Pharos
Explore in Source
Incretin synthesis, secretion, and inactivation
Metabolism of proteins
Peptide hormone metabolism
SRP-dependent cotranslational protein targeting to membrane
Synthesis, secretion, and deacylation of Ghrelin
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (196)
1 – 10 of 196
SPCS3
Tbio
Family: Enzyme
Novelty: 0.13677259
p_int: 0.999736228
p_ni: 0.000116961
p_wrong: 0.000146811
Score: 0.998
Data Source: BioPlex,STRINGDB
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
p_int: 0.993858326
p_ni: 0.000243738
p_wrong: 0.005897936
Score: 0.998
Data Source: BioPlex,STRINGDB
PRTN3
Tchem
Family: Enzyme
Novelty: 0.00022728
p_int: 0.976080227
p_ni: 0.005873529
p_wrong: 0.018046244
Data Source: BioPlex
PRSS21
Tbio
Family: Enzyme
Novelty: 0.0110251
p_int: 0.974176659
p_ni: 0.009137352
p_wrong: 0.01668599
Data Source: BioPlex
ST3GAL3
Tbio
Family: Enzyme
Novelty: 0.01592595
p_int: 0.974004509
p_ni: 0.004683099
p_wrong: 0.021312392
Data Source: BioPlex
ARSK
Tbio
Family: Enzyme
Novelty: 0.11486213
p_int: 0.96977884
p_ni: 0.010056688
p_wrong: 0.020164472
Data Source: BioPlex
DNASE1L1
Tbio
Family: Enzyme
Novelty: 0.03020646
p_int: 0.967772809
p_ni: 0.019746039
p_wrong: 0.012481152
Score: 0.834
Data Source: BioPlex,STRINGDB
SEC11A
Tbio
Family: Enzyme
Novelty: 0.05764568
p_int: 0.960071098
p_ni: 0.004469262
p_wrong: 0.03545964
Score: 0.996
Data Source: BioPlex,STRINGDB
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.95692983
p_ni: 0.029609879
p_wrong: 0.013460291
Data Source: BioPlex
GABRA3
Tclin
Family: IC
Novelty: 0.02180091
p_int: 0.941794973
p_ni: 0.054136907
p_wrong: 0.00406812
Score: 0.534
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.49

PubMed score by year
PubTator Score  17.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer