Tbio SPCS1 Signal peptidase complex subunit 1

Protein Summary

Description

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Uniprot Accession IDs

• Q9Y6A9
• B3KNF8
• Q9BVW1

Gene Name

• SPCS1

Ensembl ID

• ENST00000602728
• ENSP00000473265
• ENSG00000114902

Symbol

• SPC12
• SPC1
• SPC12
• HSPC033
• YJR010C-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
histone modification site profile	0.91
transcription factor perturbation	0.91
kinase perturbation	0.88
cell type or tissue	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Signal Peptidase Complex Subunit 1

DTO Classes

Protein / Signaling / Signal Peptidase Complex Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.81   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.81   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0