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Tbio
TACC3
Transforming acidic coiled-coil-containing protein 3

Protein Summary
Description
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313288
  • ENSP00000326550
  • ENSG00000013810

Symbol
  • ERIC1
  • ERIC1
  • ERIC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.84
transcription factor
0.7
PubMedID
0.68
small molecule perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.45   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.45   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
3
1.1
97.4
bladder carcinoma
4
2
0
1.2
94.3
osteoarthritis, hip
1
1
0
1.1
45.8
mean reticulocyte volume
1
1
1
33.7
balding measurement
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
97.4
bladder carcinoma
0
1.2
94.3
osteoarthritis, hip
0
1.1
45.8
mean reticulocyte volume
1
33.7
balding measurement
1
6.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming acidic coiled-coil containing protein 3
VGNC:12846
461066
Macaque
transforming acidic coiled-coil containing protein 3
712898
Mouse
MGI:1341163
21335
Rat
RGD:1302948
360962
Dog
transforming acidic coiled-coil containing protein 3
VGNC:53244
479079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming acidic coiled-coil containing protein 3
Macaque
transforming acidic coiled-coil containing protein 3
Mouse
Rat
Dog
transforming acidic coiled-coil containing protein 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6A5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
NOTCH3 Activation and Transmission of Signal to the Nucleus (R-HSA-9013507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
NOTCH3 Activation and Transmission of Signal to the Nucleus
Reactome
Negative regulation of NOTCH4 signaling
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH3
Name
Explore in Pharos
Explore in Source
NOTCH3 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH3
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (200)
1 – 10 of 200
PLEKHO2
Tdark
Novelty: 0.48296621
p_int: 0.999999831
p_ni: 1.69e-7
Data Source: BioPlex
CRISP2
Tbio
Novelty: 0.01862113
p_int: 0.999992612
p_ni: 0.000007388
Score: 0.188
Data Source: BioPlex,STRINGDB
SNAP29
Tbio
Novelty: 0.02009206
p_int: 0.999831788
p_ni: 0.000168212
Data Source: BioPlex
CORO6
Tdark
Novelty: 0.37416507
p_int: 0.999788103
p_ni: 0.000211897
Data Source: BioPlex
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.998882918
p_ni: 0.001116857
p_wrong: 2.25e-7
Data Source: BioPlex
SPERT
Tbio
Novelty: 0.12255061
p_int: 0.996874665
p_ni: 0.003125333
p_wrong: 1e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
EVL
Tbio
Novelty: 0.03533257
p_int: 0.996634781
p_ni: 0.003096769
p_wrong: 0.000268449
Score: 0.156
Data Source: BioPlex,STRINGDB
SLAIN2
Tbio
Novelty: 0.16273974
p_int: 0.996593141
p_ni: 0.003406853
p_wrong: 6e-9
Score: 0.281
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.996477703
p_ni: 0.003522238
p_wrong: 5.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.99354058
p_ni: 0.00645942
Data Source: BioPlex
Publication Statistics
PubMed Score  151.45

PubMed score by year
PubTator Score  91.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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