Tbio CFAP20 Cilia- and flagella-associated protein 20

Protein Summary

Description

Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207).

Uniprot Accession IDs

• Q9Y6A4

Gene Name

• CFAP20

Ensembl ID

• ENST00000262498
• ENSP00000262498
• ENSG00000070761

Symbol

• BUG22
• C16orf80
• GTL3
• GTL3
• BUG22
• EVORF
• fSAP23
• C16orf80

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.9
kinase perturbation	0.84
transcription factor	0.66
cellular component	0.64
cell type or tissue	0.58

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Cilia- And Flagella-associated Protein 20

Protein / Nucleic Acid Binding / Nuclease / Cilia- And Flagella-associated Protein 20

DTO Classes

Protein / Enzyme / Nuclease / Cilia- And Flagella-associated Protein 20

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.63   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.63   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0