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Tchem
CYP46A1
Cholesterol 24-hydroxylase

Protein Summary
Description
Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261835
  • ENSP00000261835
  • ENSG00000036530
  • ENST00000380228
  • ENSP00000369577

Symbol
  • CYP46
  • CP46
  • CYP46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.75
pathway
0.7
molecular function
0.63
cellular component
0.61
histone modification site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.23   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.23   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
voriconazole
Rendered image for voriconazole
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
5
4
1.1
91.4
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
91.4
0
1.1
31.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 46 subfamily A member 1
VGNC:7521
453154
Macaque
cholesterol 24-hydroxylase
705843
Mouse
MGI:1341877
13116
Rat
RGD:1306605
362782
Dog
cytochrome P450 family 46 subfamily A member 1
VGNC:50360
480432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 46 subfamily A member 1
Macaque
cholesterol 24-hydroxylase
Mouse
Rat
Dog
cytochrome P450 family 46 subfamily A member 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6A2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Endogenous sterols
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Metabolism
Protein-Protein Interactions (56)
1 – 10 of 56
CYP39A1
Tbio
Family:  Enzyme
Novelty:  0.0556276
Score:  0.974
Data Source:  STRINGDB
CH25H
Tbio
Family:  Enzyme
Novelty:  0.01620877
Score:  0.971
Data Source:  STRINGDB
CYP7A1
Tchem
Family:  Enzyme
Novelty:  0.00148194
Score:  0.964
Data Source:  STRINGDB
CYP27A1
Tchem
Family:  Enzyme
Novelty:  0.00071796
Score:  0.941
Data Source:  STRINGDB
DHCR7
Tchem
Family:  Enzyme
Novelty:  0.00358937
Score:  0.907
Data Source:  STRINGDB
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
Score:  0.906
Data Source:  STRINGDB
DHCR24
Tchem
Family:  Enzyme
Novelty:  0.00480473
Score:  0.897
Data Source:  STRINGDB
LIPA
Tchem
Family:  Enzyme
Novelty:  0.00164907
Score:  0.824
Data Source:  STRINGDB
CEL
Tchem
Family:  Enzyme
Novelty:  0.00156761
Score:  0.821
Data Source:  STRINGDB
SOAT2
Tchem
Family:  Enzyme
Novelty:  0.01860981
Score:  0.818
Data Source:  STRINGDB
Publication Statistics
PubMed Score  68.23

PubMed score by year
PubTator Score  86.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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