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Tbio
CACNG2
Voltage-dependent calcium channel gamma-2 subunit

Protein Summary
Description
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause an autosomal dominant form of cognitive disability. [provided b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300105
  • ENSP00000300105
  • ENSG00000166862

Symbol
  • MRD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cell type or tissue
0.8
microRNA
0.68
cellular component
0.52
phenotype
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.16   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.16   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (183)
HBS1L
Tbio
Novelty:  0.00125579
p_int:  0.999757836
p_ni:  0.000242164
Score:  0.179
Data Source:  BioPlex,STRINGDB
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
p_int:  0.995776158
p_ni:  0.004223842
Score:  0.254
Data Source:  BioPlex,STRINGDB
GOPC
Tchem
Novelty:  0.01110168
p_int:  0.992339599
p_ni:  0.007660401
Score:  0.349
Data Source:  BioPlex,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
p_int:  0.986765395
p_ni:  0.013234589
p_wrong:  1.6e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
CCNT1
Tchem
Novelty:  0.00526848
p_int:  0.983987462
p_ni:  0.016012471
p_wrong:  6.7e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
CSNK1D
Tchem
Family:  Kinase
Novelty:  0.00896935
p_int:  0.975570729
p_ni:  0.024428793
p_wrong:  4.78e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
p_int:  0.972770241
p_ni:  0.027229759
Score:  0.193
Data Source:  BioPlex,STRINGDB
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.968551685
p_ni:  0.031448315
Score:  0.237
Data Source:  BioPlex,STRINGDB
ATF1
Tchem
Family:  TF
Novelty:  0.01450941
p_int:  0.934594513
p_ni:  0.000540023
p_wrong:  0.064865464
Score:  0.234
Data Source:  BioPlex,STRINGDB
MSTO1
Tbio
Novelty:  0.05914188
p_int:  0.851316594
p_ni:  0.145028025
p_wrong:  0.003655381
Score:  0.163
Data Source:  BioPlex,STRINGDB
Pathways (27)
Cardiac conduction (R-HSA-5576891)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
LGI-ADAM interactions
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Developmental Biology
Glutamate binding, activation of AMPA receptors and synaptic plasticity
LGI-ADAM interactions
Muscle contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 2
VGNC:12823
458799
Macaque
calcium voltage-gated channel auxiliary subunit gamma 2
696294
Mouse
MGI:1316660
12300
Rat
RGD:71095
84347
Dog
calcium voltage-gated channel auxiliary subunit gamma 2
VGNC:38648
481279
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 2
Macaque
calcium voltage-gated channel auxiliary subunit gamma 2
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit gamma 2
Publication Statistics
PubMed Score 126.16
PubMed score by year
PubTator Score 60.05
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title