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Tbio
NFS1
Cysteine desulfurase, mitochondrial

Protein Classes
Protein Summary
Description
Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374085
  • ENSP00000363198
  • ENSG00000244005
  • ENST00000374092
  • ENSP00000363205
  • ENST00000397425
  • ENSP00000380570
  • ENST00000541387
  • ENSP00000440897

Symbol
  • NIFS
  • IscS
  • NIFS
  • HUSSY-08
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
protein domain
0.92
histone modification site profile
0.87
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.5   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.5   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
7
97.7
BMI-adjusted hip circumference
2
14
17
95.9
suntan
1
2
2
89.7
low density lipoprotein cholesterol measurement
2
2
2
71.4
total cholesterol measurement
1
1
1
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
97.7
BMI-adjusted hip circumference
17
95.9
suntan
2
89.7
low density lipoprotein cholesterol measurement
2
71.4
total cholesterol measurement
1
64
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NFS1, cysteine desulfurase
VGNC:14264
107970007
Macaque
NFS1, cysteine desulfurase
704077
Mouse
MGI:1316706
18041
Rat
RGD:620912
84594
Dog
NFS1, cysteine desulfurase
477214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NFS1, cysteine desulfurase
Macaque
NFS1, cysteine desulfurase
Mouse
Rat
Dog
NFS1, cysteine desulfurase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y697-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Reactome
Molybdenum cofactor biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Mitochondrial iron-sulfur cluster biogenesis
Molybdenum cofactor biosynthesis
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (127)
1 – 10 of 127
CDNF
Tbio
Novelty:  0.02100131
p_int:  0.99998979
p_ni:  0.00001021
Score:  0.303
Data Source:  BioPlex,STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
p_int:  0.999894205
p_ni:  0.000105795
Score:  0.803
Data Source:  BioPlex,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.999832671
p_ni:  0.000167329
Score:  0.178
Data Source:  BioPlex,STRINGDB
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.999717749
p_ni:  0.000282251
Data Source:  BioPlex
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.99814082
p_ni:  0.00185918
Data Source:  BioPlex
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.996905117
p_ni:  0.003094883
Data Source:  BioPlex
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.994457716
p_ni:  0.005542284
Score:  0.447
Data Source:  BioPlex,STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
p_int:  0.993676859
p_ni:  0.006323141
Score:  0.292
Data Source:  BioPlex,STRINGDB
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.982062878
p_ni:  0.017937122
Data Source:  BioPlex
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
p_int:  0.971327269
p_ni:  0.028672731
Data Source:  BioPlex
Publication Statistics
PubMed Score  74.50

PubMed score by year
PubTator Score  86.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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