Tbio NFS1 Cysteine desulfurase, mitochondrial

Protein Summary

Description

Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q9Y697
• B3KMA5
• B4DXK9
• E1P5R8
• F5GYK5
• Q6P0L8
• Q9NTZ5
• Q9Y481

Gene Name

• NFS1

Ensembl ID

• ENST00000374085
• ENSP00000363198
• ENSG00000244005
• ENST00000374092
• ENSP00000363205
• ENST00000397425
• ENSP00000380570
• ENST00000541387
• ENSP00000440897

Symbol

• NIFS
• IscS
• NIFS
• HUSSY-08

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.95
protein domain	0.92
histone modification site profile	0.87
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Lyase / Cysteine Desulfurase, Mitochondrial

DTO Classes

Protein / Enzyme / Lyase / Cysteine Desulfurase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.8   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.8   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0