Tbio CLIC4 Chloride intracellular channel protein 4

Protein Summary

Description

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y696
• Q9UFW9
• Q9UQJ6

Gene Name

• CLIC4

Ensembl ID

• ENST00000374379
• ENSP00000363500
• ENSG00000169504
• ENST00000488683
• ENSP00000436538

Symbol

• H1
• huH1
• p64H1
• CLIC4L
• MTCLIC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
transcription factor perturbation	0.97
transcription factor binding site profile	0.95
kinase perturbation	0.93
virus perturbation	0.92

Protein Classes

DTO Classes

Protein / Ion Channel / Intracellular Chloride Channel (Clic) Family / Chloride Intracellular Channel Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.53   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 312   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.53   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0