You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KCNMB2
Calcium-activated potassium channel subunit beta-2

Protein Classes
Protein Summary
Description
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358316
  • ENSP00000351068
  • ENSG00000197584
  • ENST00000420517
  • ENSP00000408252
  • ENST00000432997
  • ENSP00000407592
  • ENST00000452583
  • ENSP00000397483
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
phenotype
0.73
cell type or tissue
0.7
tissue sample
0.63
microRNA
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
1
0
1
34.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1
34.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily M regulatory beta subunit 2
VGNC:53367
460857
Macaque
potassium calcium-activated channel subfamily M regulatory beta subunit 2
710221
Mouse
MGI:1919663
72413
Rat
RGD:631398
294961
Dog
potassium calcium-activated channel subfamily M regulatory beta subunit 2
VGNC:54103
488179
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily M regulatory beta subunit 2
Macaque
potassium calcium-activated channel subfamily M regulatory beta subunit 2
Mouse
Rat
Dog
potassium calcium-activated channel subfamily M regulatory beta subunit 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Hemostasis
Reactome
Neuronal System
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Hemostasis
Neuronal System
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Protein-Protein Interactions (22)
1 – 10 of 22
KCNMA1
Tclin
Family: IC
Novelty: 0.00088182
Score: 0.916
Data Source: Reactome,STRINGDB
KCNU1
Tbio
Family: IC
Novelty: 0.02284336
Score: 0.846
Data Source: STRINGDB
KCNMB4
Tbio
Family: IC
Novelty: 0.05362954
Score: 0.821
Data Source: Reactome,STRINGDB
KCNN3
Tchem
Family: IC
Novelty: 0.00227544
Score: 0.817
Data Source: STRINGDB
KCNMB3
Tbio
Family: IC
Novelty: 0.08717845
Score: 0.812
Data Source: Reactome,STRINGDB
KCNMB1
Tbio
Family: IC
Novelty: 0.00736653
Score: 0.811
Data Source: Reactome,STRINGDB
KCNN2
Tchem
Family: IC
Novelty: 0.01865346
Score: 0.808
Data Source: STRINGDB
KCNN1
Tchem
Family: IC
Novelty: 0.04266994
Score: 0.807
Data Source: STRINGDB
KCNN4
Tchem
Family: IC
Novelty: 0.00244935
Score: 0.804
Data Source: STRINGDB
PRKG1
Tchem
Family: Kinase
Novelty: 0.0014943
Score: 0.8
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  0.75

PubMed score by year
PubTator Score  7763.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer