Tbio ARL5A ADP-ribosylation factor-like protein 5A

Protein Summary

Description

Lacks ADP-ribosylation enhancing activity. The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y689
• Q580I5

Gene Name

• ARL5A

Ensembl ID

• ENST00000295087
• ENSP00000295087
• ENSG00000162980
• ENST00000428992
• ENSP00000415950
• ENST00000446896
• ENSP00000394626

Symbol

• ARFLP5
• ARL5
• ARL5
• ARFLP5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
disease perturbation	0.95
kinase perturbation	0.91
molecular function	0.73
interacting protein	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0