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Tbio
ARL5A
ADP-ribosylation factor-like protein 5A

Protein Summary
Description
Lacks ADP-ribosylation enhancing activity. The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295087
  • ENSP00000295087
  • ENSG00000162980
  • ENST00000428992
  • ENSP00000415950
  • ENST00000446896
  • ENSP00000394626

Symbol
  • ARFLP5
  • ARL5
  • ARL5
  • ARFLP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.95
kinase perturbation
0.91
molecular function
0.73
interacting protein
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
RASL12
Tbio
Family:  Enzyme
Novelty:  0.08794239
Score:  0.651
Data Source:  STRINGDB
TBC1D23
Tbio
Novelty:  0.18566729
Score:  0.628
Data Source:  STRINGDB
ARFGAP3
Tbio
Family:  Enzyme
Novelty:  0.02542172
Score:  0.627
Data Source:  STRINGDB
VPS54
Tbio
Novelty:  0.04428383
Score:  0.601
Data Source:  STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
Score:  0.591
Data Source:  STRINGDB
CACNB2
Tbio
Family:  IC
Novelty:  0.01745218
Score:  0.571
Data Source:  STRINGDB
AGFG1
Tbio
Novelty:  0.00121561
Score:  0.57
Data Source:  STRINGDB
VPS53
Tbio
Novelty:  0.07513165
Score:  0.562
Data Source:  STRINGDB
VPS51
Tbio
Novelty:  0.01766125
Score:  0.549
Data Source:  STRINGDB
RASL11B
Tbio
Family:  Enzyme
Novelty:  0.21040396
Score:  0.544
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
2
3
84.8
idiopathic dilated cardiomyopathy
1
1
0
1
36
1
1
0
19
29.3
self reported educational attainment
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
84.8
idiopathic dilated cardiomyopathy
0
1
36
0
19
29.3
self reported educational attainment
1
22.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 5A
VGNC:77
736445
Macaque
ADP ribosylation factor like GTPase 5A
100430437
Mouse
MGI:1922673
75423
Rat
RGD:621327
117050
Dog
ADP ribosylation factor like GTPase 5A
VGNC:38115
100683961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 5A
Macaque
ADP ribosylation factor like GTPase 5A
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 5A
Publication Statistics
PubMed Score 9.96
PubMed score by year
PubTator Score 4.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title