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Tbio
MRPS18B
28S ribosomal protein S18b, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259873
  • ENSP00000259873
  • ENSG00000204568
  • ENST00000327800
  • ENSP00000383438
  • ENSG00000203624
  • ENST00000412451
  • ENSP00000402718
  • ENSG00000223775
  • ENST00000426945
  • ENSP00000397790
  • ENSG00000229861
  • ENST00000430402
  • ENSP00000398494
  • ENSG00000233813
  • ENST00000451032
  • ENSP00000415703
  • ENSG00000226111
  • ENST00000454427
  • ENSP00000414972
  • ENSG00000227420

Symbol
  • C6orf14
  • PTD017
  • S18amt
  • C6orf14
  • HSPC183
  • MRPS18-2
  • HumanS18a
  • MRP-S18-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
co-expressed gene
0.89
interacting protein
0.89
virus perturbation
0.79
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.58   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.58   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
6.1
70.7
1
1
0
6.1
70.7
1
1
0
6.1
70.7
1
1
0
6.1
70.7
1
1
0
6.1
70.7
Items per page:
1 – 5 of 7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
6.1
70.7
0
6.1
70.7
0
6.1
70.7
0
6.1
70.7
0
6.1
70.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S18B
VGNC:11126
462545
Macaque
mitochondrial ribosomal protein S18B
713694
Mouse
MGI:1914223
66973
Rat
RGD:1302998
294230
Dog
mitochondrial ribosomal protein S18B
VGNC:43413
474827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S18B
Macaque
mitochondrial ribosomal protein S18B
Mouse
Rat
Dog
mitochondrial ribosomal protein S18B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y676-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (167)
1 – 10 of 167
NOA1
Tbio
Novelty: 0.01478325
p_int: 0.999993732
p_ni: 0.000006256
p_wrong: 1.2e-8
Score: 0.436
Data Source: BioPlex,STRINGDB
NDUFAF7
Tbio
Family: Enzyme
Novelty: 0.24691414
p_int: 0.998844508
p_ni: 0.001155492
Score: 0.197
Data Source: BioPlex,STRINGDB
MRPS5
Tbio
Novelty: 0.11423336
p_int: 0.99850006
p_ni: 0.00149994
Score: 0.99
Data Source: BioPlex,STRINGDB
DAP3
Tbio
Novelty: 0.05551866
p_int: 0.998430101
p_ni: 0.001569899
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPS2
Tbio
Novelty: 0.14756204
p_int: 0.998363849
p_ni: 0.001636151
Score: 0.999
Data Source: BioPlex,STRINGDB
PTCD3
Tbio
Novelty: 0.12368434
p_int: 0.998332677
p_ni: 0.001667323
Score: 0.999
Data Source: BioPlex,STRINGDB
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.998158347
p_ni: 0.001841653
Data Source: BioPlex
MRPS35
Tdark
Novelty: 6.44240335
p_int: 0.997987569
p_ni: 0.002012431
Score: 0.998
Data Source: BioPlex,STRINGDB
POLG
Tchem
Family: Enzyme
Novelty: 0.00172189
p_int: 0.997765767
p_ni: 0.002234233
Data Source: BioPlex
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.997705857
p_ni: 0.002294143
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.58

PubMed score by year
PubTator Score  3.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer