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Tbio
ALG6
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

Protein Summary
Description
Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263440
  • ENSP00000263440
  • ENSG00000088035
  • ENST00000371108
  • ENSP00000360149

Symbol
  • CDG1C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
microRNA
0.63
cell type or tissue
0.61
virus perturbation
0.59
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
p_int:  0.999951882
p_ni:  0.000048044
p_wrong:  7.4e-8
Data Source:  BioPlex
ALG8
Tbio
Family:  Enzyme
Novelty:  0.03721075
p_int:  0.986585811
p_ni:  0.013413718
p_wrong:  4.7e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
TAX1BP1
Tbio
Novelty:  0.02498501
p_int:  0.964666923
p_ni:  0.035333077
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.962667858
p_ni:  0.037326777
p_wrong:  0.000005366
Score:  0.167
Data Source:  BioPlex,STRINGDB
NDFIP1
Tbio
Novelty:  0.04496467
p_int:  0.93022815
p_ni:  0.0696335
p_wrong:  0.00013835
Data Source:  BioPlex
GOLM1
Tbio
Novelty:  0.00752112
p_int:  0.921037019
p_ni:  0.07896277
p_wrong:  2.12e-7
Data Source:  BioPlex
LRP10
Tbio
Novelty:  0.04049684
p_int:  0.872777314
p_ni:  0.127147949
p_wrong:  0.000074737
Data Source:  BioPlex
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
p_int:  0.860317692
p_ni:  0.000099779
p_wrong:  0.139582529
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.831278312
p_ni:  0.168721688
Data Source:  BioPlex
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.790801924
p_ni:  0.209198076
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective ALG6 causes ALG6-CDG (CDG-1c)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG6 causes ALG6-CDG (CDG-1c)
Disease
Diseases associated with N-glycosylation of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
35
hematocrit
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
35
hematocrit
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALG6, alpha-1,3-glucosyltransferase
VGNC:78
456906
Macaque
ALG6, alpha-1,3-glucosyltransferase
696323
Mouse
MGI:2444031
320438
Rat
RGD:1308815
362547
Dog
ALG6, alpha-1,3-glucosyltransferase
VGNC:37800
609974
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALG6, alpha-1,3-glucosyltransferase
Macaque
ALG6, alpha-1,3-glucosyltransferase
Mouse
Rat
Dog
ALG6, alpha-1,3-glucosyltransferase
Publication Statistics
PubMed Score 38.85
PubMed score by year
PubTator Score 25.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title