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Tbio
KPTN
KICSTOR complex protein kaptin

Protein Summary
Description
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. This gene encodes a filamentous-actin-associated protein, which is involved in actin dynamics and plays an important role in neuromorphogenesis. This protein is part of the KICSTOR protein complex that localizes to lysosomes. Mutations in this gene result in an autosomal recessive form of intellectual disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338134
  • ENSP00000337850
  • ENSG00000118162

Symbol
  • 2E4
  • MRT41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.72
cellular component
0.69
gene perturbation
0.65
small molecule perturbation
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.42   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.42   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kaptin, actin binding protein
VGNC:13202
456166
Macaque
kaptin, actin binding protein
717322
Mouse
MGI:1890380
70394
Dog
kaptin, actin binding protein
VGNC:42507
612136
Horse
kaptin, actin binding protein
VGNC:19512
100146519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kaptin, actin binding protein
Macaque
kaptin, actin binding protein
Mouse
Dog
kaptin, actin binding protein
Horse
kaptin, actin binding protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y664-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (63)
1 – 10 of 63
ITFG2
Tbio
Novelty: 0.41720651
p_int: 1
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
SZT2
Tbio
Novelty: 0.06995258
p_int: 0.999999416
p_ni: 5.84e-7
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
C12orf66
Tbio
Novelty: 1.38775963
p_int: 0.999999342
p_ni: 1.43e-7
p_wrong: 5.15e-7
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
VWCE
Tbio
Novelty: 0.09328341
p_int: 0.99999815
p_ni: 0.000001849
Data Source: BioPlex
TMCO4
Tdark
Novelty: 0.70043428
p_int: 0.999993681
p_wrong: 0.000006319
Score: 0.332
Data Source: BioPlex,STRINGDB
SEC14L1
Tbio
Novelty: 0.09562071
p_int: 0.999976577
p_ni: 0.000023384
p_wrong: 3.9e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
NFRKB
Tbio
Novelty: 0.13445983
p_int: 0.999863347
p_ni: 0.000136653
Data Source: BioPlex
KLC4
Tdark
Novelty: 0.32552746
p_int: 0.999794615
p_ni: 0.000205385
Score: 0.173
Data Source: BioPlex,STRINGDB
PROSER2
Tdark
Novelty: 0.56334611
p_int: 0.99964806
p_ni: 0.00035194
Data Source: BioPlex
BMT2
Tbio
Family: Enzyme
Novelty: 0.05916379
p_int: 0.999471227
p_ni: 0.000528581
p_wrong: 1.92e-7
Score: 0.667
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  14.42

PubMed score by year
PubTator Score  4.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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