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Tbio
SPIN1
Spindlin-1

Protein Summary
Description
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375859
  • ENSP00000365019
  • ENSG00000106723

Symbol
  • OCR
  • SPIN
  • SPIN
  • TDRD24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.98
virus perturbation
0.85
transcription factor binding site profile
0.77
histone modification site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.6   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.6   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (33)
1 – 10 of 33
SPINDOC
Tdark
Novelty: 0.70981211
p_int: 1
Score: 0.91
Data Source: BioPlex,STRINGDB
SPIN2B
Tdark
Novelty: 0.23202718
p_int: 1
Score: 0.814
Data Source: BioPlex,STRINGDB
CGGBP1
Tbio
Novelty: 0.10880271
p_int: 0.999999582
p_ni: 4.18e-7
Score: 0.825
Data Source: BioPlex,STRINGDB
YRDC
Tdark
Novelty: 0.01240103
p_int: 0.999936655
p_ni: 0.000063345
Score: 0.85
Data Source: BioPlex,STRINGDB
TOPORS
Tbio
Family: Enzyme
Novelty: 0.03910082
p_int: 0.999901912
p_ni: 0.000098086
p_wrong: 2e-9
Score: 0.738
Data Source: BioPlex,STRINGDB
SCNM1
Tbio
Novelty: 0.19700548
p_int: 0.999807211
p_ni: 0.000192405
p_wrong: 3.84e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
ZNF324B
Tdark
Family: TF
Novelty: 1.89922228
p_int: 0.999286877
p_ni: 0.000713123
Data Source: BioPlex
ZGPAT
Tbio
Family: Epigenetic
Novelty: 0.16971298
p_int: 0.999061123
p_ni: 0.000935412
p_wrong: 0.000003465
Score: 0.259
Data Source: BioPlex,STRINGDB
PAX3
Tbio
Family: TF
Novelty: 0.00140464
p_int: 0.952767386
p_ni: 8.06e-7
p_wrong: 0.047231809
Score: 0.356
Data Source: BioPlex,STRINGDB
SF3A3
Tbio
Novelty: 0.03815499
p_int: 0.763672599
p_ni: 0.236327401
Score: 0.413
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  121.60

PubMed score by year
PubTator Score  6644.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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