Protein Summary
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
- ENST00000375859
- ENSP00000365019
- ENSG00000106723
- OCR
- SPIN
- SPIN
- TDRD24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
transcription factor perturbation | 0.98 | ||
virus perturbation | 0.85 | ||
transcription factor binding site profile | 0.77 | ||
histone modification site profile | 0.71 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.27 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.27 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (13)
1 – 10 of 13
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 1 | 1 | 1 | 4.5 | |||||
heel bone mineral density | 1 | 1 | 1 | 1.9 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 1 | 4.5 | |||||
heel bone mineral density | 1 | 1.9 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | spindlin 1 | VGNC:4869 | 464577 | |||||
Macaque | spindlin 1 | 695862 | ||||||
Mouse | MGI:109242 | 20729 | ||||||
Rat | RGD:1306210 | 361217 | ||||||
Dog | spindlin 1 | VGNC:46742 | 476353 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | spindlin 1 | |||||
Macaque | spindlin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | spindlin 1 | |||||
Protein Structure (8 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 8
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Gene Ontology Terms (15)
Functions (1)
Components (6)
Processes (8)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (33)
1 – 10 of 33
SPINDOC
Novelty: 0.70981211
p_int: 1
Score: 0.91
Data Source: BioPlex,STRINGDB
SPIN2B
Novelty: 0.23202718
p_int: 1
Score: 0.814
Data Source: BioPlex,STRINGDB
CGGBP1
Novelty: 0.10880271
p_int: 0.999999582
p_ni: 4.18e-7
Score: 0.825
Data Source: BioPlex,STRINGDB
YRDC
Novelty: 0.01240103
p_int: 0.999936655
p_ni: 0.000063345
Score: 0.85
Data Source: BioPlex,STRINGDB
TOPORS
Family: Enzyme
Novelty: 0.03910082
p_int: 0.999901912
p_ni: 0.000098086
p_wrong: 2e-9
Score: 0.738
Data Source: BioPlex,STRINGDB
SCNM1
Novelty: 0.19700548
p_int: 0.999807211
p_ni: 0.000192405
p_wrong: 3.84e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
ZNF324B
Family: TF
Novelty: 1.89922228
p_int: 0.999286877
p_ni: 0.000713123
Data Source: BioPlex
ZGPAT
Family: Epigenetic
Novelty: 0.16971298
p_int: 0.999061123
p_ni: 0.000935412
p_wrong: 0.000003465
Score: 0.259
Data Source: BioPlex,STRINGDB
PAX3
Family: TF
Novelty: 0.00140464
p_int: 0.952767386
p_ni: 8.06e-7
p_wrong: 0.047231809
Score: 0.356
Data Source: BioPlex,STRINGDB
SF3A3
Novelty: 0.03815499
p_int: 0.763672599
p_ni: 0.236327401
Score: 0.413
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 124.27
PubMed score by year
PubTator Score 6644.78
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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