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Tchem
SPIN1
Spindlin-1

Protein Summary
Description
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375859
  • ENSP00000365019
  • ENSG00000106723

Symbol
  • OCR
  • SPIN
  • SPIN
  • TDRD24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.98
virus perturbation
0.85
transcription factor binding site profile
0.77
histone modification site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.27   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.27   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
4.5
heel bone mineral density
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
4.5
heel bone mineral density
1
1.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spindlin 1
VGNC:4869
464577
Macaque
spindlin 1
695862
Mouse
MGI:109242
20729
Rat
RGD:1306210
361217
Dog
spindlin 1
VGNC:46742
476353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spindlin 1
Macaque
spindlin 1
Mouse
Rat
Dog
spindlin 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y657-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (33)
1 – 10 of 33
SPINDOC
Tdark
Novelty:  0.70981211
p_int:  1
Score:  0.91
Data Source:  BioPlex,STRINGDB
SPIN2B
Tchem
Novelty:  0.23202718
p_int:  1
Score:  0.814
Data Source:  BioPlex,STRINGDB
CGGBP1
Tbio
Novelty:  0.10880271
p_int:  0.999999582
p_ni:  4.18e-7
Score:  0.825
Data Source:  BioPlex,STRINGDB
YRDC
Tdark
Novelty:  0.01240103
p_int:  0.999936655
p_ni:  0.000063345
Score:  0.85
Data Source:  BioPlex,STRINGDB
TOPORS
Tbio
Family:  Enzyme
Novelty:  0.03910082
p_int:  0.999901912
p_ni:  0.000098086
p_wrong:  2e-9
Score:  0.738
Data Source:  BioPlex,STRINGDB
SCNM1
Tbio
Novelty:  0.19700548
p_int:  0.999807211
p_ni:  0.000192405
p_wrong:  3.84e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.999286877
p_ni:  0.000713123
Data Source:  BioPlex
ZGPAT
Tbio
Family:  Epigenetic
Novelty:  0.16971298
p_int:  0.999061123
p_ni:  0.000935412
p_wrong:  0.000003465
Score:  0.259
Data Source:  BioPlex,STRINGDB
PAX3
Tbio
Family:  TF
Novelty:  0.00140464
p_int:  0.952767386
p_ni:  8.06e-7
p_wrong:  0.047231809
Score:  0.356
Data Source:  BioPlex,STRINGDB
SF3A3
Tbio
Novelty:  0.03815499
p_int:  0.763672599
p_ni:  0.236327401
Score:  0.413
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  124.27

PubMed score by year
PubTator Score  6644.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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