Tbio SPIN1 Spindlin-1

Protein Summary

Description

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Uniprot Accession IDs

• Q9Y657
• A8K0X6
• B3KRQ4
• Q7KZJ8
• Q9GZT2
• Q9H0N7

Gene Name

• SPIN1

Ensembl ID

• ENST00000375859
• ENSP00000365019
• ENSG00000106723

Symbol

• OCR
• SPIN
• SPIN
• TDRD24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.98
virus perturbation	0.85
transcription factor binding site profile	0.77
histone modification site profile	0.71

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.37   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.37   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (8)

1 – 5 of 8

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (15)

Functions (1)

Components (6)

Processes (8)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
methylated histone binding	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (33)

Explore Interacting Targets

1 – 10 of 33

• See Interactions on String-DB

SPINDOC

Tdark

Novelty: 4

p_int: 1

Score: 0.91

Data Source: BioPlex,STRINGDB

SPIN2B

Tbio

Novelty: 0.03496843

p_int: 1

Score: 0.814

Data Source: BioPlex,STRINGDB

CGGBP1

Tbio

Novelty: 0.09064411

p_int: 0.999999582

p_ni: 4.18e-7

Score: 0.825

Data Source: BioPlex,STRINGDB

YRDC

Tdark

Novelty: 0.01588082

p_int: 0.999936655

p_ni: 0.000063345

Score: 0.85

Data Source: BioPlex,STRINGDB

TOPORS

Tbio

Family: Enzyme

Novelty: 0.01054772

p_int: 0.999901912

p_ni: 0.000098086

p_wrong: 2e-9

Score: 0.738

Data Source: BioPlex,STRINGDB

SCNM1

Tdark

Novelty: 0.24120603

p_int: 0.999807211

p_ni: 0.000192405

p_wrong: 3.84e-7

Score: 0.188

Data Source: BioPlex,STRINGDB

ZNF324B

Tdark

Family: TF

Novelty: 2.4

p_int: 0.999286877

p_ni: 0.000713123

Data Source: BioPlex

ZGPAT

Tbio

Family: Epigenetic

Novelty: 0.3373494

p_int: 0.999061123

p_ni: 0.000935412

p_wrong: 0.000003465

Score: 0.259

Data Source: BioPlex,STRINGDB

PAX3

Tbio

Family: TF

Novelty: 0.00139998

p_int: 0.952767386

p_ni: 8.06e-7

p_wrong: 0.047231809

Score: 0.356

Data Source: BioPlex,STRINGDB

SF3A3

Tbio

Novelty: 0.05151585

p_int: 0.763672599

p_ni: 0.236327401

Score: 0.413

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  115.37

PubMed score by year

Reset Zoom

PubTator Score  6644.78

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVT

1-70

QWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHM

70-140

FETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVV

140-210

DSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS

210-262

MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Cell cycle
Chromatin regulator
Complete proteome
Developmental protein
Isopeptide bond
Meiosis
Nucleus
Phosphoprotein