ADGRG1
Adhesion G-protein coupled receptor G1
Protein Classes
Protein Summary
Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity). ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA produ ...more
- ENST00000388813
- ENSP00000373465
- ENSG00000205336
- ENST00000456916
- ENSP00000398034
- ENST00000540164
- ENSP00000444911
- ENST00000562558
- ENSP00000456620
- ENST00000562631
- ENSP00000455351
- ENST00000567835
- ENSP00000456794
- ENST00000568908
- ENSP00000457456
- ENST00000568909
- ENSP00000455215
- GPR56
- TM7LN4
- TM7XN1
- BFPP
- BPPR
- GPR56
- TM7LN4
- TM7XN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.93 | ||
PubMedID | 0.88 | ||
transcription factor | 0.85 | ||
biological process | 0.68 | ||
transcription factor perturbation | 0.68 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.48 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 283 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.48 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 283 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.2 | 61.8 | |||||
mosaic loss of chromosome Y measurement | 2 | 1 | 2 | 50.6 | |||||
platelet crit | 1 | 1 | 1 | 48.5 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 47.7 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 61.8 | |||||
mosaic loss of chromosome Y measurement | 2 | 50.6 | |||||
platelet crit | 1 | 48.5 | |||||
mean corpuscular hemoglobin concentration | 1 | 47.7 | |||||
mean reticulocyte volume | 1 | 44.2 | |||||
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | adhesion G protein-coupled receptor G1 | 613233 | ||||||
Mouse | MGI:1340051 | 14766 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | adhesion G protein-coupled receptor G1 | |||||
Mouse | ||||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (1)
WikiPathways (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | GPCRs, Other | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GPCRs, Other | ||||
Gene Ontology Terms (29)
Functions (4)
Components (5)
Processes (20)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Protein-Protein Interactions (60)
1 – 10 of 60
TGM2
Family: Enzyme
Novelty: 0.0005293
Score: 0.674
Data Source: STRINGDB
ISM1
Novelty: 0.03082946
Score: 0.661
Data Source: STRINGDB
ARHGAP18
Family: Enzyme
Novelty: 0.10618156
Score: 0.659
Data Source: STRINGDB
MMRN2
Novelty: 0.11135003
Score: 0.651
Data Source: STRINGDB
ZNF24
Family: TF
Novelty: 0.02954446
Score: 0.649
Data Source: STRINGDB
TBL2
Novelty: 0.04754985
Score: 0.623
Data Source: STRINGDB
TRNP1
Novelty: 0.12089157
Score: 0.612
Data Source: STRINGDB
ADGRA1
Family: GPCR
Novelty: 0.24926468
Score: 0.6
Data Source: STRINGDB
RFX4
Family: TF
Novelty: 0.06465996
Score: 0.561
Data Source: STRINGDB
EIF4H
Novelty: 0.03604365
Score: 0.544
Data Source: STRINGDB
Publication Statistics
PubMed Score 136.48
PubMed score by year
PubTator Score 74.08
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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GWAS Trait
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