ADGRG1
Adhesion G-protein coupled receptor G1
Protein Summary
Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity). ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA produ ...more
- ENST00000388813
- ENSP00000373465
- ENSG00000205336
- ENST00000456916
- ENSP00000398034
- ENST00000540164
- ENSP00000444911
- ENST00000562558
- ENSP00000456620
- ENST00000562631
- ENSP00000455351
- ENST00000567835
- ENSP00000456794
- ENST00000568908
- ENSP00000457456
- ENST00000568909
- ENSP00000455215
- GPR56
- TM7LN4
- TM7XN1
- BFPP
- BPPR
- GPR56
- TM7LN4
- TM7XN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.93 | ||
PubMedID | 0.88 | ||
transcription factor | 0.85 | ||
biological process | 0.68 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.48 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 283 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.48 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 283 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | GPCRs, Other | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GPCRs, Other | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (4)
Components (5)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.2 | 61.8 | |||||
mosaic loss of chromosome Y measurement | 2 | 1 | 2 | 50.6 | |||||
platelet crit | 1 | 1 | 1 | 48.5 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 47.7 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 61.8 | |||||
mosaic loss of chromosome Y measurement | 2 | 50.6 | |||||
platelet crit | 1 | 48.5 | |||||
mean corpuscular hemoglobin concentration | 1 | 47.7 | |||||
mean reticulocyte volume | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | adhesion G protein-coupled receptor G1 | 613233 | ||||||
Mouse | MGI:1340051 | 14766 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | adhesion G protein-coupled receptor G1 | |||||
Mouse | ||||||
Publication Statistics
PubMed Score 136.48
PubMed score by year
PubTator Score 74.08
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (61)
GeneRif Annotations (43)
Items per page:
0 of 0
PMID | Year | Title |
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