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Tbio
ADGRG1
Adhesion G-protein coupled receptor G1

Protein Summary
Description
Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity). ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA produ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388813
  • ENSP00000373465
  • ENSG00000205336
  • ENST00000456916
  • ENSP00000398034
  • ENST00000540164
  • ENSP00000444911
  • ENST00000562558
  • ENSP00000456620
  • ENST00000562631
  • ENSP00000455351
  • ENST00000567835
  • ENSP00000456794
  • ENST00000568908
  • ENSP00000457456
  • ENST00000568909
  • ENSP00000455215

Symbol
  • GPR56
  • TM7LN4
  • TM7XN1
  • BFPP
  • BPPR
  • GPR56
  • TM7LN4
  • TM7XN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
PubMedID
0.88
transcription factor
0.85
biological process
0.68
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.48   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.48   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
61.8
mosaic loss of chromosome Y measurement
2
1
2
50.6
platelet crit
1
1
1
48.5
mean corpuscular hemoglobin concentration
1
1
1
47.7
mean reticulocyte volume
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
61.8
mosaic loss of chromosome Y measurement
2
50.6
platelet crit
1
48.5
mean corpuscular hemoglobin concentration
1
47.7
mean reticulocyte volume
1
44.2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y653-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (29)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (60)
1 – 10 of 60
TGM2
Tchem
Family:  Enzyme
Novelty:  0.0005293
Score:  0.674
Data Source:  STRINGDB
ISM1
Tbio
Novelty:  0.03082946
Score:  0.661
Data Source:  STRINGDB
ARHGAP18
Tbio
Family:  Enzyme
Novelty:  0.10618156
Score:  0.659
Data Source:  STRINGDB
MMRN2
Tbio
Novelty:  0.11135003
Score:  0.651
Data Source:  STRINGDB
ZNF24
Tbio
Family:  TF
Novelty:  0.02954446
Score:  0.649
Data Source:  STRINGDB
TBL2
Tbio
Novelty:  0.04754985
Score:  0.623
Data Source:  STRINGDB
TRNP1
Tdark
Novelty:  0.12089157
Score:  0.612
Data Source:  STRINGDB
ADGRA1
Tbio
Family:  GPCR
Novelty:  0.24926468
Score:  0.6
Data Source:  STRINGDB
RFX4
Tbio
Family:  TF
Novelty:  0.06465996
Score:  0.561
Data Source:  STRINGDB
EIF4H
Tchem
Novelty:  0.03604365
Score:  0.544
Data Source:  STRINGDB
Publication Statistics
PubMed Score  136.48

PubMed score by year
PubTator Score  74.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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