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Tbio
ADGRG1
Adhesion G-protein coupled receptor G1

Protein Summary
Description
Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity). ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA produ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388813
  • ENSP00000373465
  • ENSG00000205336
  • ENST00000456916
  • ENSP00000398034
  • ENST00000540164
  • ENSP00000444911
  • ENST00000562558
  • ENSP00000456620
  • ENST00000562631
  • ENSP00000455351
  • ENST00000567835
  • ENSP00000456794
  • ENST00000568908
  • ENSP00000457456
  • ENST00000568909
  • ENSP00000455215

Symbol
  • GPR56
  • TM7LN4
  • TM7XN1
  • BFPP
  • BPPR
  • GPR56
  • TM7LN4
  • TM7XN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
PubMedID
0.88
transcription factor
0.85
biological process
0.68
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.89   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.89   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0