RFNG
Beta-1,3-N-acetylglucosaminyltransferase radical fringe
Protein Summary
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.
- ENST00000310496
- ENSP00000307971
- ENSG00000169733
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
histone modification site profile | 0.88 | ||
transcription factor perturbation | 0.8 | ||
tissue sample | 0.7 | ||
cellular component | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.13 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 108 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.13 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 108 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0