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Tdark
RFNG
Beta-1,3-N-acetylglucosaminyltransferase radical fringe

Protein Summary
Description
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310496
  • ENSP00000307971
  • ENSG00000169733
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.88
transcription factor perturbation
0.8
tissue sample
0.7
cellular component
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.01   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.01   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
6
76.5
vital capacity
1
1
1
73.2
blood metabolite measurement
1
1
1
57.3
birth weight
2
2
2
55.2
BMI-adjusted waist-hip ratio
2
2
2
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
76.5
vital capacity
1
73.2
blood metabolite measurement
1
57.3
birth weight
2
55.2
BMI-adjusted waist-hip ratio
2
48.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
719330
Mouse
MGI:894275
19719
Rat
RGD:621322
60433
Dog
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
VGNC:45499
483376
Horse
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:HGNC Symbol;Acc:HGNC:9974]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Mouse
Rat
Dog
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Horse
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:HGNC Symbol;Acc:HGNC:9974]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y644-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1189)
Pre-NOTCH Expression and Processing (R-HSA-1912422)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Pre-NOTCH Expression and Processing
Reactome
Pre-NOTCH Processing in Golgi
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Name
Explore in Pharos
Explore in Source
Pre-NOTCH Expression and Processing
Pre-NOTCH Processing in Golgi
Signal Transduction
Signaling by NOTCH
Protein-Protein Interactions (35)
1 – 10 of 35
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.861336432
p_ni:  0.000106728
p_wrong:  0.13855684
Data Source:  BioPlex
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.969
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.955
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.952
Data Source:  STRINGDB
NOTCH4
Tchem
Novelty:  0.00471643
Score:  0.932
Data Source:  STRINGDB
LFNG
Tbio
Family:  Enzyme
Novelty:  0.02660238
Score:  0.81
Data Source:  STRINGDB
MFNG
Tbio
Family:  Enzyme
Novelty:  0.09624431
Score:  0.81
Data Source:  STRINGDB
JAG1
Tbio
Novelty:  0.00107618
Score:  0.684
Data Source:  STRINGDB
JAG2
Tbio
Novelty:  0.00176158
Score:  0.647
Data Source:  STRINGDB
POFUT1
Tbio
Family:  Enzyme
Novelty:  0.0176011
Score:  0.641
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.01

PubMed score by year
PubTator Score  1.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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