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Tbio
NPTN
Neuroplastin

Protein Summary
Description
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345330
  • ENSP00000290401
  • ENSG00000156642
  • ENST00000351217
  • ENSP00000342958
  • ENST00000562924
  • ENSP00000456349
  • ENST00000563691
  • ENSP00000457028

Symbol
  • SDFR1
  • SDR1
  • GP55
  • GP65
  • SDR1
  • np55
  • np65
  • SDFR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.91
protein domain
0.85
biological process
0.79
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.37   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.37   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.927
Data Source:  Reactome,STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.919
Data Source:  STRINGDB
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
Score:  0.917
Data Source:  Reactome,STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.914
Data Source:  STRINGDB
GABRB1
Tclin
Family:  IC
Novelty:  0.02895574
Score:  0.909
Data Source:  Reactome,STRINGDB
GABRA2
Tclin
Family:  IC
Novelty:  0.00663529
Score:  0.907
Data Source:  STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.907
Data Source:  STRINGDB
ARHGEF9
Tbio
Novelty:  0.01577146
Score:  0.905
Data Source:  STRINGDB
GABRB3
Tclin
Family:  IC
Novelty:  0.00485997
Score:  0.904
Data Source:  Reactome,STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
4
3
2.4
97.8
aspartate aminotransferase measurement
2
2
1
8.2
78.7
serum alanine aminotransferase measurement
2
1
1
9
74.6
sex hormone-binding globulin measurement
3
1
3
40.7
FEV/FEC ratio
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
2.4
97.8
aspartate aminotransferase measurement
1
8.2
78.7
serum alanine aminotransferase measurement
1
9
74.6
sex hormone-binding globulin measurement
3
40.7
FEV/FEC ratio
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuroplastin
VGNC:1905
453732
Macaque
neuroplastin
699627
Mouse
MGI:108077
20320
Rat
RGD:620296
56064
Dog
neuroplastin
VGNC:43932
487637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuroplastin
Macaque
neuroplastin
Mouse
Rat
Dog
neuroplastin
Publication Statistics
PubMed Score 257.37
PubMed score by year
PubTator Score 82.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title