Protein Summary
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
- ENST00000345330
- ENSP00000290401
- ENSG00000156642
- ENST00000351217
- ENSP00000342958
- ENST00000562924
- ENSP00000456349
- ENST00000563691
- ENSP00000457028
- SDFR1
- SDR1
- GP55
- GP65
- SDR1
- np55
- np65
- SDFR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
transcription factor perturbation | 0.91 | ||
protein domain | 0.85 | ||
biological process | 0.79 | ||
transcription factor binding site profile | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 257.37 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 294 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 257.37 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 294 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (53)
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | GABA receptor activation | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Reactome | Transmission across Chemical Synapses | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GABA receptor activation | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Transmission across Chemical Synapses | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (4)
Components (11)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | HGNC | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 4 | 4 | 3 | 2.4 | 97.8 | ||||
aspartate aminotransferase measurement | 2 | 2 | 1 | 8.2 | 78.7 | ||||
serum alanine aminotransferase measurement | 2 | 1 | 1 | 9 | 74.6 | ||||
sex hormone-binding globulin measurement | 3 | 1 | 3 | 40.7 | |||||
FEV/FEC ratio | 1 | 1 | 1 | 37.6 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 3 | 2.4 | 97.8 | ||||
aspartate aminotransferase measurement | 1 | 8.2 | 78.7 | ||||
serum alanine aminotransferase measurement | 1 | 9 | 74.6 | ||||
sex hormone-binding globulin measurement | 3 | 40.7 | |||||
FEV/FEC ratio | 1 | 37.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neuroplastin | VGNC:1905 | 453732 | |||||
Macaque | neuroplastin | 699627 | ||||||
Mouse | MGI:108077 | 20320 | ||||||
Rat | RGD:620296 | 56064 | ||||||
Dog | neuroplastin | VGNC:43932 | 487637 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neuroplastin | |||||
Macaque | neuroplastin | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuroplastin | |||||
Publication Statistics
PubMed Score 257.37
PubMed score by year
PubTator Score 82.39
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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