NPTN
Neuroplastin
Protein Summary
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
- ENST00000345330
- ENSP00000290401
- ENSG00000156642
- ENST00000351217
- ENSP00000342958
- ENST00000562924
- ENSP00000456349
- ENST00000563691
- ENSP00000457028
- SDFR1
- SDR1
- GP55
- GP65
- SDR1
- np55
- np65
- SDFR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
transcription factor perturbation | 0.91 | ||
protein domain | 0.85 | ||
biological process | 0.79 | ||
transcription factor binding site profile | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 278.73 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 294 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 278.73 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 294 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0