Protein Summary
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
- ENST00000377047
- ENSP00000366246
- ENSG00000183098
- OMIMD1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
pathway | 0.97 | ||
interacting protein | 0.85 | ||
transcription factor perturbation | 0.84 | ||
PubMedID | 0.78 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.94 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 192 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.94 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 192 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (103)
1 – 10 of 103
GPC4
Novelty: 0.01319626
p_int: 0.999999995
p_ni: 5e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
HADHA
Novelty: 0.00385746
p_int: 0.993974773
p_ni: 0.006025227
Data Source: BioPlex
GPR183
Family: GPCR
Novelty: 0.02005679
p_int: 0.975205987
p_ni: 0.024794013
Score: 0.538
Data Source: BioPlex,STRINGDB
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.917063826
p_ni: 0.082936174
Score: 0.22
Data Source: BioPlex,STRINGDB
DLX4
Family: TF
Novelty: 0.01959238
p_int: 0.879617943
p_ni: 0.120382057
Score: 0.372
Data Source: BioPlex,STRINGDB
MRPS7
Novelty: 0.00153134
p_int: 0.879617943
p_ni: 0.120382057
Score: 0.186
Data Source: BioPlex,STRINGDB
SDC2
Novelty: 0.00597758
Score: 0.978
Data Source: STRINGDB
HSPG2
Family: Enzyme
Novelty: 0.00159541
Score: 0.976
Data Source: STRINGDB
EXT1
Family: Enzyme
Novelty: 0.00355951
Score: 0.97
Data Source: STRINGDB
SDC1
Novelty: 0.00044792
Score: 0.969
Data Source: STRINGDB
Pathways (25)
Reactome (24)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 24
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Reactome | Defective B3GAT3 causes JDSSDHD | ||||
Reactome | Defective B4GALT7 causes EDS, progeroid type | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Defective B3GAT3 causes JDSSDHD | ||||
Defective B4GALT7 causes EDS, progeroid type | ||||
Gene Ontology Terms (15)
Functions (1)
Components (8)
Processes (6)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | ParkinsonsUK-UCL | |||
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 9 | 12 | 96.8 | |||||
chronotype measurement | 2 | 2 | 1 | 1 | 71.8 | ||||
wellbeing measurement | 3 | 2 | 3 | 52.3 | |||||
refractive error measurement | 2 | 2 | 1 | 6.2 | 40.5 | ||||
depressive symptom measurement | 1 | 1 | 1 | 39.6 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 12 | 96.8 | |||||
chronotype measurement | 1 | 1 | 71.8 | ||||
wellbeing measurement | 3 | 52.3 | |||||
refractive error measurement | 1 | 6.2 | 40.5 | ||||
depressive symptom measurement | 1 | 39.6 | |||||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
GWAS Trait
No Header | No Header | ||
|---|---|---|---|
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glypican 6 | VGNC:13111 | 452621 | |||||
Mouse | MGI:1346322 | 23888 | ||||||
Chicken | glypican 6 | CGNC:12684 | 418794 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glypican 6 | |||||
Mouse | ||||||
Chicken | glypican 6 | |||||
Publication Statistics
PubMed Score 46.94
PubMed score by year
PubTator Score 16.81
PubTator score by year