Tbio GPC6 Glypican-6

Protein Summary

Description

Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]

Uniprot Accession IDs

• Q9Y625
• A8K279
• Q96SG5
• Q96SG8
• Q9H1P4

Gene Name

• GPC6

Ensembl ID

• ENST00000377047
• ENSP00000366246
• ENSG00000183098

Symbol

• OMIMD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
pathway	0.97
interacting protein	0.85
transcription factor perturbation	0.84
PubMedID	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.8   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 192   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.8   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0