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Tbio
F11R
Junctional adhesion molecule A

Protein Summary
Description
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368026
  • ENSP00000357005
  • ENSG00000158769
  • ENST00000537746
  • ENSP00000440812

Symbol
  • JAM1
  • JCAM
  • JAM
  • KAT
  • JAM1
  • JAMA
  • JCAM
  • CD321
  • PAM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.89
kinase perturbation
0.84
virus perturbation
0.83
transcription factor
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.4   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 557   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.4   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 557   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
77.7
leukocyte count
1
1
1
75.7
monocyte percentage of leukocytes
1
1
1
55.2
granulocyte percentage of myeloid white cells
1
1
1
42.3
granulocyte count
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
77.7
leukocyte count
1
75.7
monocyte percentage of leukocytes
1
55.2
granulocyte percentage of myeloid white cells
1
42.3
granulocyte count
1
6.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F11 receptor
719824
Mouse
MGI:1321398
16456
Rat
RGD:621842
116479
Horse
F11 receptor
VGNC:49312
100066720
Cow
F11 receptor
VGNC:50010
281258
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F11 receptor
Mouse
Rat
Horse
F11 receptor
Cow
F11 receptor
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y624-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell surface interactions at the vascular wall
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell surface interactions at the vascular wall
Cell-Cell communication
Cell-cell junction organization
Extracellular matrix organization
Gene Ontology Terms (28)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (113)
1 – 10 of 113
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.999858212
p_ni:  2.33e-7
p_wrong:  0.000141555
Score:  0.454
Data Source:  BioPlex,STRINGDB
IL12A
Tclin
Novelty:  0.05943184
p_int:  0.981391895
p_ni:  1.61e-7
p_wrong:  0.018607944
Score:  0.416
Data Source:  BioPlex,STRINGDB
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.894974823
p_ni:  1.7e-7
p_wrong:  0.105025007
Score:  0.193
Data Source:  BioPlex,STRINGDB
AFDN
Tbio
Novelty:  0.00372947
Score:  0.99
Data Source:  STRINGDB
TJP1
Tbio
Novelty:  0.00040365
Score:  0.984
Data Source:  STRINGDB
CGN
Tbio
Novelty:  0.01097394
Score:  0.979
Data Source:  STRINGDB
PARD3
Tbio
Novelty:  0.00521327
Score:  0.978
Data Source:  Reactome,STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.961
Data Source:  Reactome,STRINGDB
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
Score:  0.955
Data Source:  STRINGDB
CLDN1
Tbio
Novelty:  0.00505039
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  591.40

PubMed score by year
PubTator Score  1393.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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