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Tbio
RAD54B
DNA repair and recombination protein RAD54B

Protein Summary
Description
Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297592
  • ENSP00000430153
  • ENSG00000197275
  • ENST00000336148
  • ENSP00000336606

Symbol
  • RDH54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.89
transcription factor binding site profile
0.73
virus perturbation
0.72
cell type or tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.96   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.96   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
CPNE5
Tbio
Novelty:  0.09416684
p_int:  0.999999998
p_ni:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
MAF1
Tbio
Family:  Enzyme
Novelty:  0.01060279
p_int:  0.910624016
p_ni:  0.000004635
p_wrong:  0.089371348
Score:  0.335
Data Source:  BioPlex,STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.986
Data Source:  STRINGDB
RAD52
Tchem
Novelty:  0.00125282
Score:  0.937
Data Source:  STRINGDB
BLM
Tchem
Novelty:  0.00662454
Score:  0.887
Data Source:  STRINGDB
WRN
Tbio
Family:  Enzyme
Novelty:  0.00163164
Score:  0.886
Data Source:  STRINGDB
DMC1
Tbio
Novelty:  0.05445277
Score:  0.882
Data Source:  STRINGDB
RAD51D
Tbio
Novelty:  0.01422516
Score:  0.867
Data Source:  STRINGDB
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
Score:  0.865
Data Source:  STRINGDB
RAD54L
Tbio
Novelty:  0.03646892
Score:  0.859
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
3
4
78.6
1
2
0
1.2
67.5
Cleft palate
1
2
0
1.2
67.5
serum non-albumin protein measurement
1
1
1
54.4
blood protein measurement
1
1
1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
78.6
0
1.2
67.5
Cleft palate
0
1.2
67.5
serum non-albumin protein measurement
1
54.4
blood protein measurement
1
9.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD54 homolog B (S. cerevisiae)
472821
Macaque
RAD54 homolog B (S. cerevisiae)
699516
Mouse
MGI:3605986
623474
Rat
RGD:1306507
313063
Dog
RAD54 homolog B
VGNC:54119
487053
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD54 homolog B (S. cerevisiae)
Macaque
RAD54 homolog B (S. cerevisiae)
Mouse
Rat
Dog
RAD54 homolog B
Publication Statistics
PubMed Score 46.96
PubMed score by year
PubTator Score 17.77
PubTator score by year
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Related Publications
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PMID
Year
Title