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Tchem
NCOR2
Nuclear receptor corepressor 2

Protein Summary
Description
Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405201
  • ENSP00000384018
  • ENSG00000196498

Symbol
  • CTG26
  • SMRT
  • TRAC
  • CTG26
  • SMRTE
  • TRAC1
  • N-CoR2
  • TNRC14
  • TRAC-1
  • SMAP270
  • SMRTE-tau
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
disease perturbation
0.95
transcription factor binding site profile
0.89
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1545.9   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1545.9   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
3
3
91.1
appendicular lean mass
3
1
3
82.5
BMI-adjusted hip circumference
3
12
13
79.2
serum gamma-glutamyl transferase measurement
1
1
1
77.7
diastolic blood pressure
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
91.1
appendicular lean mass
3
82.5
BMI-adjusted hip circumference
13
79.2
serum gamma-glutamyl transferase measurement
1
77.7
diastolic blood pressure
1
68.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor corepressor 2
VGNC:13330
467150
Mouse
MGI:1337080
20602
Rat
RGD:1310293
360801
Dog
nuclear receptor corepressor 2
VGNC:52954
486242
Horse
nuclear receptor corepressor 2
VGNC:49497
100146720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor corepressor 2
Mouse
Rat
Dog
nuclear receptor corepressor 2
Horse
nuclear receptor corepressor 2
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y618-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (82)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Developmental Biology
Gene Ontology Terms (23)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (354)
1 – 10 of 354
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.999999998
p_ni:  2e-9
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
TBL1Y
Tbio
p_int:  0.999999989
p_ni:  1.1e-8
Data Source:  BioPlex
ZSCAN5A
Tdark
Family:  TF
Novelty:  2.15267128
p_int:  0.980719855
p_ni:  0.019277002
p_wrong:  0.000003142
Score:  0.308
Data Source:  BioPlex,STRINGDB
DGKG
Tbio
Family:  Enzyme
Novelty:  0.03666646
p_int:  0.955392762
p_ni:  0.036494535
p_wrong:  0.008112703
Data Source:  BioPlex
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.999
Data Source:  Reactome,STRINGDB
TBL1X
Tbio
Novelty:  0.00027212
Score:  0.997
Data Source:  Reactome,STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.997
Data Source:  Reactome,STRINGDB
TBL1XR1
Tbio
Novelty:  0.00503043
Score:  0.995
Data Source:  Reactome,STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.995
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.994
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1545.90

PubMed score by year
PubTator Score  265.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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