Tchem NCOR2 Nuclear receptor corepressor 2

Protein Summary

Description

Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• Q9Y618
• O00613
• O15416
• O15421
• Q13354
• Q56D06
• Q59GM0
• Q9Y5U0
• N-CoR2

Gene Name

• NCOR2

Ensembl ID

• ENST00000405201
• ENSP00000384018
• ENSG00000196498

Symbol

• CTG26
• SMRT
• TRAC
• CTG26
• SMRTE
• TRAC1
• N-CoR2
• TNRC14
• TRAC-1
• SMAP270
• SMRTE-tau

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
disease perturbation	0.95
transcription factor binding site profile	0.89
transcription factor perturbation	0.84
ligand (protein) perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Nuclear Receptor Corepressor 2

Protein / Nucleic Acid Binding / Nuclear Receptor Corepressor 2

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Nuclear Receptor Corepressor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1886.96   (req: < 5)

Gene RIFs: 91   (req: <= 3)

Antibodies: 247   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1886.96   (req: >= 5)

Gene RIFs: 91   (req: > 3)

Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2