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Tbio
PSAT1
Phosphoserine aminotransferase

Protein Summary
Description
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347159
  • ENSP00000317606
  • ENSG00000135069
  • ENST00000376588
  • ENSP00000365773

Symbol
  • PSA
  • PSA
  • EPIP
  • NLS2
  • PSAT
  • PSATD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
gene perturbation
0.97
small molecule perturbation
0.96
transcription factor perturbation
0.96
disease perturbation
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.15   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.15   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
MPRIP
Tbio
Family:  Enzyme
Novelty:  0.03253403
p_int:  0.847552999
p_ni:  0.152415514
p_wrong:  0.000031487
Score:  0.507
Data Source:  BioPlex,STRINGDB
PHGDH
Tchem
Family:  Enzyme
Novelty:  0.00047542
Score:  0.999
Data Source:  STRINGDB
PSPH
Tbio
Family:  Enzyme
Novelty:  0.01078634
Score:  0.996
Data Source:  STRINGDB
VPS29
Tbio
Novelty:  0.01335106
Score:  0.9
Data Source:  STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.868
Data Source:  STRINGDB
ALDH18A1
Tbio
Family:  Enzyme
Novelty:  0.00301673
Score:  0.834
Data Source:  STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.822
Data Source:  STRINGDB
ASNS
Tchem
Family:  Enzyme
Novelty:  0.00337445
Score:  0.817
Data Source:  STRINGDB
SHTN1
Tbio
Novelty:  0.06452923
Score:  0.817
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.799
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (46)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Serine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Serine biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
10.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoserine aminotransferase 1
VGNC:53289
464542
Macaque
phosphoserine aminotransferase 1
706387
Mouse
MGI:2183441
107272
Rat
RGD:735170
293820
Dog
phosphoserine aminotransferase 1
VGNC:45081
476318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoserine aminotransferase 1
Macaque
phosphoserine aminotransferase 1
Mouse
Rat
Dog
phosphoserine aminotransferase 1
Publication Statistics
PubMed Score 273.15
PubMed score by year
PubTator Score 114.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title