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Tbio
ACTL7A
Actin-like protein 7A

Protein Summary
Description
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333999
  • ENSP00000334300
  • ENSG00000187003
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.77
gene perturbation
0.76
cell type or tissue
0.57
cellular component
0.57
cell line
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.32   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.32   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (57)
1 – 10 of 57
TES
Tbio
Novelty: 0.00112939
Score: 0.961
Data Source: STRINGDB
ENAH
Tbio
Novelty: 0.03560604
Score: 0.872
Data Source: STRINGDB
CTNNAL1
Tbio
Novelty: 0.07754085
Score: 0.796
Data Source: STRINGDB
UBQLNL
Tdark
Novelty: 0.26885736
Score: 0.727
Data Source: STRINGDB
ELP1
Tbio
Novelty: 0.00109618
Score: 0.717
Data Source: STRINGDB
HDGFL1
Tdark
Family: Epigenetic
Novelty: 0.17168552
Score: 0.68
Data Source: STRINGDB
CAPZA3
Tdark
Novelty: 0.25693073
Score: 0.68
Data Source: STRINGDB
CCIN
Tbio
Novelty: 0.05842259
Score: 0.619
Data Source: STRINGDB
MMEL1
Tchem
Family: Enzyme
Novelty: 0.03193354
Score: 0.603
Data Source: STRINGDB
FTMT
Tbio
Novelty: 0.02104947
Score: 0.588
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.32

PubMed score by year
PubTator Score  3.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer