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Tbio
ACTL7A
Actin-like protein 7A

Protein Summary
Description
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333999
  • ENSP00000334300
  • ENSG00000187003
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.77
gene perturbation
0.76
cell type or tissue
0.57
cellular component
0.57
cell line
0.49


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.64   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.64   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin like 7A
VGNC:4598
464642
Macaque
actin like 7A
710653
Mouse
MGI:1343051
11470
Rat
RGD:1304697
298017
Dog
actin like 7A
VGNC:37544
474795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin like 7A
Macaque
actin like 7A
Mouse
Rat
Dog
actin like 7A
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (57)
1 – 10 of 57
TES
Tbio
Novelty: 0.00052221
Score: 0.961
Data Source: STRINGDB
ENAH
Tbio
Novelty: 0.02329247
Score: 0.872
Data Source: STRINGDB
CTNNAL1
Tbio
Novelty: 0.03667606
Score: 0.796
Data Source: STRINGDB
UBQLNL
Tdark
Novelty: 0.48160388
Score: 0.727
Data Source: STRINGDB
ELP1
Tbio
Novelty: 0.0035777
Score: 0.717
Data Source: STRINGDB
HDGFL1
Tdark
Family: Epigenetic
Novelty: 0.14333428
Score: 0.68
Data Source: STRINGDB
CAPZA3
Tdark
Novelty: 0.27080401
Score: 0.68
Data Source: STRINGDB
CCIN
Tbio
Novelty: 0.05318622
Score: 0.619
Data Source: STRINGDB
MMEL1
Tchem
Family: Enzyme
Novelty: 0.02700936
Score: 0.603
Data Source: STRINGDB
FTMT
Tbio
Novelty: 0.01843809
Score: 0.588
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.64

PubMed score by year
PubTator Score  3.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer