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Tbio
MRFAP1
MORF4 family-associated protein 1

Protein Summary
Description
This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320912
  • ENSP00000318352
  • ENSG00000179010
  • ENST00000382581
  • ENSP00000372024
  • ENST00000507420
  • ENSP00000422065

Symbol
  • PAM14
  • PGR1
  • PGR1
  • PAM14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
small molecule perturbation
0.99
disease perturbation
0.93
transcription factor binding site profile
0.71
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
p_int:  0.999902979
p_ni:  0.000097021
Score:  0.917
Data Source:  BioPlex,STRINGDB
MORF4L2
Tbio
Novelty:  0.09897629
p_int:  0.999888618
p_ni:  0.000111382
Score:  0.943
Data Source:  BioPlex,STRINGDB
C14orf93
Tdark
Novelty:  0.33588613
p_int:  0.999851213
p_ni:  8.2e-8
p_wrong:  0.000148706
Score:  0.224
Data Source:  BioPlex,STRINGDB
IK
Tbio
Novelty:  0.01510642
p_int:  0.993496121
p_ni:  0.006503878
Data Source:  BioPlex
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.982705838
p_ni:  0.017294162
Data Source:  BioPlex
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
p_int:  0.94754577
p_ni:  0.05245423
Data Source:  BioPlex
CEP97
Tbio
Novelty:  0.12709162
p_int:  0.903305567
p_ni:  0.096694433
Data Source:  BioPlex
HAUS1
Tbio
Novelty:  0.11356375
p_int:  0.836959695
p_ni:  0.163024885
p_wrong:  0.00001542
Data Source:  BioPlex
ARFGAP2
Tbio
Family:  Enzyme
Novelty:  0.08758647
Score:  0.778
Data Source:  STRINGDB
MRFAP1L1
Tdark
Novelty:  0.87470289
Score:  0.738
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Morf4 family associated protein 1
710771
Mouse
MGI:1914818
67568
Dog
Morf4 family associated protein 1
608548
Horse
MORF4 family-associated protein 1
100056426
Horse
MORF4 family-associated protein 1-like
100056513
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Morf4 family associated protein 1
Mouse
Dog
Morf4 family associated protein 1
Horse
MORF4 family-associated protein 1
Horse
MORF4 family-associated protein 1-like
Publication Statistics
PubMed Score 9.96
PubMed score by year
PubTator Score 7.28
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title