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Tbio
ETV7
Transcription factor ETV7

Protein Summary
Description
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity. The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339796
  • ENSP00000342260
  • ENSG00000010030
  • ENST00000340181
  • ENSP00000341843
  • ENST00000373737
  • ENSP00000362842
  • ENST00000373738
  • ENSP00000362843
  • ENST00000538992
  • ENSP00000440592
  • ENST00000615781
  • ENSP00000481885
  • ENST00000620358
  • ENSP00000484485
  • ENST00000627426
  • ENSP00000486712

Symbol
  • TEL2
  • TELB
  • TREF
  • TEL2
  • TELB
  • TEL-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
tissue sample
0.64
molecular function
0.63
histone modification site profile
0.59
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
3
93.7
platelet count
3
3
2
5
93.6
2
2
0
1.1
83.2
leukocyte count
1
1
1
38.2
1
1
2
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
93.7
platelet count
2
5
93.6
0
1.1
83.2
leukocyte count
1
38.2
2
33.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ETS variant 7
VGNC:2780
747854
Macaque
ETS variant 7
719151
Dog
ETS variant 7
VGNC:40501
481764
Horse
ETS variant 7
VGNC:17707
100063827
Pig
ETS variant 7
100156210
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ETS variant 7
Macaque
ETS variant 7
Dog
ETS variant 7
Horse
ETS variant 7
Pig
ETS variant 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y603-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (39)
1 – 10 of 39
ETV6
Tbio
Family:  TF
Novelty:  0.00151718
p_int:  0.999938411
p_ni:  0.000025514
p_wrong:  0.000036074
Score:  0.911
Data Source:  BioPlex,STRINGDB
PDLIM7
Tbio
Novelty:  0.00544518
p_int:  0.98041464
p_ni:  0.019585228
p_wrong:  1.33e-7
Score:  0.537
Data Source:  BioPlex,STRINGDB
PCBD1
Tbio
Family:  Enzyme
Novelty:  0.01564376
Score:  0.654
Data Source:  STRINGDB
BHLHE22
Tbio
Family:  TF
Novelty:  0.00442982
Score:  0.566
Data Source:  STRINGDB
KIR2DL1
Tbio
Novelty:  0.00523657
Score:  0.53
Data Source:  STRINGDB
TREH
Tchem
Family:  Enzyme
Novelty:  0.00462386
Score:  0.515
Data Source:  STRINGDB
KIR2DL3
Tbio
Novelty:  0.00599644
Score:  0.512
Data Source:  STRINGDB
KIR3DL1
Tbio
Novelty:  0.00308245
Score:  0.491
Data Source:  STRINGDB
ELOVL5
Tbio
Novelty:  0.00536344
Score:  0.478
Data Source:  STRINGDB
TRIM45
Tbio
Novelty:  0.03874681
Score:  0.474
Data Source:  STRINGDB
Publication Statistics
PubMed Score  33.83

PubMed score by year
PubTator Score  28.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer