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Tbio
CSAD
Cysteine sulfinic acid decarboxylase

Protein Summary
Description
Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. This gene encodes a member of the group 2 decarboxylase family. A similar protein in rodents plays a role in multiple biological processes as the rate-limiting enzyme in taurine biosynthesis, catalyzing the decarboxylation of cysteinesulfinate to hypotaurine. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267085
  • ENSP00000267085
  • ENSG00000139631
  • ENST00000379846
  • ENSP00000369175
  • ENST00000444623
  • ENSP00000415485
  • ENST00000453446
  • ENSP00000410648

Symbol
  • CSD
  • CSD
  • PCAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.78
transcription factor binding site profile
0.76
PubMedID
0.68
tissue sample
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.57   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.57   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
CDO1
Tbio
Family:  Enzyme
Novelty:  0.01682989
Score:  0.96
Data Source:  STRINGDB
ADO
Tbio
Family:  Enzyme
Novelty:  0.04529593
Score:  0.951
Data Source:  STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
Score:  0.918
Data Source:  STRINGDB
BAAT
Tbio
Family:  Enzyme
Novelty:  0.01336714
Score:  0.916
Data Source:  STRINGDB
GGT6
Tbio
Family:  Enzyme
Novelty:  0.016069
Score:  0.911
Data Source:  STRINGDB
GGT5
Tbio
Family:  Enzyme
Novelty:  0.00602505
Score:  0.91
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.906
Data Source:  STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
Score:  0.904
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.865
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Degradation of cysteine and homocysteine (R-HSA-1614558)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
spine bone mineral density
1
1
1
57.8
self reported educational attainment
2
2
2
57.1
mathematical ability
2
2
2
45.6
intelligence
1
1
1
44.2
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
spine bone mineral density
1
57.8
self reported educational attainment
2
57.1
mathematical ability
2
45.6
intelligence
1
44.2
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine sulfinic acid decarboxylase
VGNC:5349
100612110
Macaque
cysteine sulfinic acid decarboxylase
701290
Mouse
MGI:2180098
246277
Rat
RGD:621030
60356
Dog
cysteine sulfinic acid decarboxylase
VGNC:39649
486510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine sulfinic acid decarboxylase
Macaque
cysteine sulfinic acid decarboxylase
Mouse
Rat
Dog
cysteine sulfinic acid decarboxylase
Publication Statistics
PubMed Score 83.57
PubMed score by year
PubTator Score 42.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title