Tbio UBIAD1 UbiA prenyltransferase domain-containing protein 1

Protein Summary

Description

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q9Y5Z9
• B3KQG3
• Q53GX3
• Q5THD4

Gene Name

• UBIAD1

Ensembl ID

• ENST00000376804
• ENSP00000366000
• ENSG00000120942
• ENST00000376810
• ENSP00000366006

Symbol

• TERE1
• SCCD
• TERE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.74
cellular component	0.71
transcription factor binding site profile	0.61
microRNA	0.6
transcription factor perturbation	0.54

Protein Classes

PANTHER Classes

Protein / Transferase / Ubia Prenyltransferase Domain-containing Protein 1

DTO Classes

Protein / Enzyme / Transferase / Ubia Prenyltransferase Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.24   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.24   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0