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Tbio
HCFC2
Host cell factor 2

Protein Summary
Description
This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229330
  • ENSP00000229330
  • ENSG00000111727
  • ENST00000544223
  • ENSP00000442942

Symbol
  • HCF2
  • HCF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.91
histone modification site profile
0.85
virus perturbation
0.85
interacting protein
0.82
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.73   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.73   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
KMT2B
Tbio
Family:  Epigenetic
Novelty:  0.00593529
p_int:  0.999999979
p_ni:  1.5e-8
p_wrong:  7e-9
Score:  0.878
Data Source:  BioPlex,STRINGDB
KMT2A
Tchem
Family:  Epigenetic
Novelty:  0.00192554
p_int:  0.999999828
p_ni:  1.4e-7
p_wrong:  3.2e-8
Score:  0.834
Data Source:  BioPlex,STRINGDB
CXXC1
Tbio
Family:  Epigenetic
Novelty:  0.01019251
p_int:  0.999999346
p_ni:  6.54e-7
Score:  0.754
Data Source:  BioPlex,STRINGDB
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
p_int:  0.999998326
p_ni:  0.000001674
Score:  0.59
Data Source:  BioPlex,STRINGDB
BOD1L1
Tdark
Novelty:  0.26485597
p_int:  0.999891232
p_ni:  0.000108768
Score:  0.578
Data Source:  BioPlex,STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
p_int:  0.995612611
p_ni:  0.004387389
Score:  0.898
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.99225925
p_ni:  0.00774075
Data Source:  BioPlex
CREB3
Tbio
Family:  TF
Novelty:  0.00424318
p_int:  0.992236525
p_ni:  0.007763475
Score:  0.855
Data Source:  BioPlex,STRINGDB
DIDO1
Tbio
Family:  Epigenetic
Novelty:  0.0492858
p_int:  0.991421217
p_ni:  0.008578784
Score:  0.279
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.990482396
p_ni:  0.009517604
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
2
0
3.2
88.3
vascular cell adhesion molecule-1 measurement
1
1
1
61
intraocular pressure measurement
1
1
1
57.3
corneal topography
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3.2
88.3
vascular cell adhesion molecule-1 measurement
1
61
intraocular pressure measurement
1
57.3
corneal topography
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
host cell factor C2
VGNC:54167
452190
Mouse
MGI:1915183
67933
Rat
RGD:1307385
314704
Dog
host cell factor C2
VGNC:41617
475449
Horse
host cell factor C2 [Source:HGNC Symbol;Acc:HGNC:24972]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
host cell factor C2
Mouse
Rat
Dog
host cell factor C2
Horse
host cell factor C2 [Source:HGNC Symbol;Acc:HGNC:24972]
Publication Statistics
PubMed Score 7.73
PubMed score by year
PubTator Score 18.48
PubTator score by year
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Related Publications
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PMID
Year
Title