Tbio HCFC2 Host cell factor 2

Protein Summary

Description

This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5Z7
• B2R8Q5
• C0H5X3
• HCF-2

Gene Name

• HCFC2

Ensembl ID

• ENST00000229330
• ENSP00000229330
• ENSG00000111727
• ENST00000544223
• ENSP00000442942

Symbol

• HCF2
• HCF-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.91
histone modification site profile	0.85
virus perturbation	0.85
interacting protein	0.82
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.73   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.73   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (59)

Explore Interacting Targets

1 – 10 of 59

• See Interactions on String-DB

KMT2B

Tbio

Family:  Epigenetic

Novelty:  0.00593529

p_int:  0.999999979

p_ni:  1.5e-8

p_wrong:  7e-9

Score:  0.878

Data Source:  BioPlex,STRINGDB

KMT2A

Tchem

Family:  Epigenetic

Novelty:  0.00192554

p_int:  0.999999828

p_ni:  1.4e-7

p_wrong:  3.2e-8

Score:  0.834

Data Source:  BioPlex,STRINGDB

CXXC1

Tbio

Family:  Epigenetic

Novelty:  0.01019251

p_int:  0.999999346

p_ni:  6.54e-7

Score:  0.754

Data Source:  BioPlex,STRINGDB

SETD1A

Tbio

Family:  Epigenetic

Novelty:  0.00248544

p_int:  0.999998326

p_ni:  0.000001674

Score:  0.59

Data Source:  BioPlex,STRINGDB

BOD1L1

Tdark

Novelty:  0.26485597

p_int:  0.999891232

p_ni:  0.000108768

Score:  0.578

Data Source:  BioPlex,STRINGDB

ASH2L

Tbio

Family:  Enzyme

Novelty:  0.01586766

p_int:  0.995612611

p_ni:  0.004387389

Score:  0.898

Data Source:  BioPlex,STRINGDB

CCT2

Tbio

Novelty:  0.01967139

p_int:  0.99225925

p_ni:  0.00774075

Data Source:  BioPlex

CREB3

Tbio

Family:  TF

Novelty:  0.00424318

p_int:  0.992236525

p_ni:  0.007763475

Score:  0.855

Data Source:  BioPlex,STRINGDB

DIDO1

Tbio

Family:  Epigenetic

Novelty:  0.0492858

p_int:  0.991421217

p_ni:  0.008578784

Score:  0.279

Data Source:  BioPlex,STRINGDB

CCT6B

Tdark

Novelty:  0.28933315

p_int:  0.990482396

p_ni:  0.009517604

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Herpes simplex virus 1 infection	567 targets	path:hsa05168

Name	Explore in Pharos	Explore in Source
Herpes simplex virus 1 infection	567 targets	path:hsa05168

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (1)

Components (6)

Processes (3)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
transcription coactivator activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	2	2	0	3.2	88.3
vascular cell adhesion molecule-1 measurement	EFO_0010057	1	1	1		61
intraocular pressure measurement	EFO_0004695	1	1	1		57.3
corneal topography	EFO_0004345	1	1	1		42.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	0	3.2	88.3
vascular cell adhesion molecule-1 measurement	EFO_0010057	1		61
intraocular pressure measurement	EFO_0004695	1		57.3
corneal topography	EFO_0004345	1		42.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
Isopeptide bond
Kelch repeat
Nucleus
Polymorphism
Reference proteome
Repeat
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
central corneal thickness
corneal topography
intraocular pressure measurement
vascular cell adhesion molecule-1 measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	host cell factor C2	VGNC:54167	452190
Mouse	host cell factor C2	MGI:1915183	67933
Rat	host cell factor C2	RGD:1307385	314704
Dog	host cell factor C2	VGNC:41617	475449
Horse	host cell factor C2 [Source:HGNC Symbol;Acc:HGNC:24972]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	host cell factor C2
Mouse	host cell factor C2
Rat	host cell factor C2
Dog	host cell factor C2
Horse	host cell factor C2 [Source:HGNC Symbol;Acc:HGNC:24972]

Publication Statistics

PubMed Score 7.73

PubMed score by year

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PubTator Score 18.48

PubTator score by year

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Related Publications

Text Mined References (7)

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10

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PMID	Year	Title