Protein Summary
This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]
- ENST00000229330
- ENSP00000229330
- ENSG00000111727
- ENST00000544223
- ENSP00000442942
- HCF2
- HCF-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
microRNA | 0.91 | ||
histone modification site profile | 0.85 | ||
virus perturbation | 0.85 | ||
interacting protein | 0.82 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.73 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.73 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (59)
KMT2B
Family: Epigenetic
Novelty: 0.00593529
p_int: 0.999999979
p_ni: 1.5e-8
p_wrong: 7e-9
Score: 0.878
Data Source: BioPlex,STRINGDB
KMT2A
Family: Epigenetic
Novelty: 0.00192554
p_int: 0.999999828
p_ni: 1.4e-7
p_wrong: 3.2e-8
Score: 0.834
Data Source: BioPlex,STRINGDB
CXXC1
Family: Epigenetic
Novelty: 0.01019251
p_int: 0.999999346
p_ni: 6.54e-7
Score: 0.754
Data Source: BioPlex,STRINGDB
SETD1A
Family: Epigenetic
Novelty: 0.00248544
p_int: 0.999998326
p_ni: 0.000001674
Score: 0.59
Data Source: BioPlex,STRINGDB
BOD1L1
Novelty: 0.26485597
p_int: 0.999891232
p_ni: 0.000108768
Score: 0.578
Data Source: BioPlex,STRINGDB
ASH2L
Family: Enzyme
Novelty: 0.01586766
p_int: 0.995612611
p_ni: 0.004387389
Score: 0.898
Data Source: BioPlex,STRINGDB
CREB3
Family: TF
Novelty: 0.00424318
p_int: 0.992236525
p_ni: 0.007763475
Score: 0.855
Data Source: BioPlex,STRINGDB
DIDO1
Family: Epigenetic
Novelty: 0.0492858
p_int: 0.991421217
p_ni: 0.008578784
Score: 0.279
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Herpes simplex virus 1 infection | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Herpes simplex virus 1 infection | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (1)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
central corneal thickness | 2 | 2 | 0 | 3.2 | 88.3 | ||||
vascular cell adhesion molecule-1 measurement | 1 | 1 | 1 | 61 | |||||
intraocular pressure measurement | 1 | 1 | 1 | 57.3 | |||||
corneal topography | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
central corneal thickness | 0 | 3.2 | 88.3 | ||||
vascular cell adhesion molecule-1 measurement | 1 | 61 | |||||
intraocular pressure measurement | 1 | 57.3 | |||||
corneal topography | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | host cell factor C2 | VGNC:54167 | 452190 | |||||
Mouse | MGI:1915183 | 67933 | ||||||
Rat | RGD:1307385 | 314704 | ||||||
Dog | host cell factor C2 | VGNC:41617 | 475449 | |||||
Horse | host cell factor C2 [Source:HGNC Symbol;Acc:HGNC:24972] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | host cell factor C2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | host cell factor C2 | |||||
Horse | host cell factor C2 [Source:HGNC Symbol;Acc:HGNC:24972] | |||||
Publication Statistics
PubMed Score 7.73
PubMed score by year
PubTator Score 18.48
PubTator score by year
Related Publications
Text Mined References (7)
Items per page:
0 of 0
PMID | Year | Title |
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