Tbio HEBP2 Heme-binding protein 2

Protein Summary

Description

Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• Q9Y5Z4
• Q96P57

Gene Name

• HEBP2

Ensembl ID

• ENST00000607197
• ENSP00000475750
• ENSG00000051620

Symbol

• C6orf34
• SOUL
• PP23
• SOUL
• C6orf34
• C6ORF34B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.83
PubMedID	0.69
disease perturbation	0.62
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.31   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.31   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0