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Tbio
HEBP2
Heme-binding protein 2

Protein Summary
Description
Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000607197
  • ENSP00000475750
  • ENSG00000051620

Symbol
  • C6orf34
  • SOUL
  • PP23
  • SOUL
  • C6orf34
  • C6ORF34B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.83
PubMedID
0.69
disease perturbation
0.62
tissue sample
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.76   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.76   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
heme binding protein 2
709176
Mouse
MGI:1860084
56016
Rat
RGD:1311553
308632
Dog
heme binding protein 2
VGNC:41640
100856214
Horse
heme binding protein 2
VGNC:18733
100073199
Species
Name
OMA
EggNOG
Inparanoid
Macaque
heme binding protein 2
Mouse
Rat
Dog
heme binding protein 2
Horse
heme binding protein 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5Z4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (106)
1 – 10 of 106
BCL2L1
Tchem
Novelty: 0.00018414
Score: 0.941
Data Source: STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
Score: 0.911
Data Source: STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.91
Data Source: STRINGDB
FAF2
Tbio
Novelty: 0.03048598
Score: 0.905
Data Source: STRINGDB
VAT1
Tbio
Family: Enzyme
Novelty: 0.32953676
Score: 0.902
Data Source: STRINGDB
TUBB
Tclin
Novelty: 0.0038007
Score: 0.902
Data Source: STRINGDB
PRDX6
Tbio
Novelty: 0.00180564
Score: 0.902
Data Source: STRINGDB
DPP7
Tchem
Family: Enzyme
Novelty: 0.00644738
Score: 0.902
Data Source: STRINGDB
FUCA1
Tchem
Family: Enzyme
Novelty: 0.00961721
Score: 0.902
Data Source: STRINGDB
MAN2B1
Tchem
Family: Enzyme
Novelty: 0.0051017
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.76

PubMed score by year
PubTator Score  41.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer