Tbio HEBP2 Heme-binding protein 2

Protein Summary

Description

Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• Q9Y5Z4
• Q96P57

Gene Name

• HEBP2

Ensembl ID

• ENST00000607197
• ENSP00000475750
• ENSG00000051620

Symbol

• C6orf34
• SOUL
• PP23
• SOUL
• C6orf34
• C6ORF34B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.83
PubMedID	0.69
disease perturbation	0.62
tissue sample	0.62

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.76   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.76   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	heme binding protein 2		709176
Mouse	heme binding protein 2	MGI:1860084	56016
Rat	heme binding protein 2	RGD:1311553	308632
Dog	heme binding protein 2	VGNC:41640	100856214
Horse	heme binding protein 2	VGNC:18733	100073199

Species	Name	OMA	EggNOG	Inparanoid
Macaque	heme binding protein 2
Mouse	heme binding protein 2
Rat	heme binding protein 2
Dog	heme binding protein 2
Horse	heme binding protein 2

Protein Structure (6 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y5Z4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (3)

Reactome (3)

Immune System (R-HSA-168256)

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Find Similar Targets

Items per page:

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (10)

Functions (1)

Components (5)

Processes (4)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
heme binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (106)

Explore Interacting Targets

1 – 10 of 106

• See Interactions on String-DB

BCL2L1

Tchem

Novelty: 0.00018414

Score: 0.941

Data Source: STRINGDB

PTGES2

Tchem

Family: Enzyme

Novelty: 0.01415352

Score: 0.911

Data Source: STRINGDB

GDI2

Tbio

Novelty: 0.02861013

Score: 0.91

Data Source: STRINGDB

FAF2

Tbio

Novelty: 0.03048598

Score: 0.905

Data Source: STRINGDB

VAT1

Tbio

Family: Enzyme

Novelty: 0.32953676

Score: 0.902

Data Source: STRINGDB

TUBB

Tclin

Novelty: 0.0038007

Score: 0.902

Data Source: STRINGDB

PRDX6

Tbio

Novelty: 0.00180564

Score: 0.902

Data Source: STRINGDB

DPP7

Tchem

Family: Enzyme

Novelty: 0.00644738

Score: 0.902

Data Source: STRINGDB

FUCA1

Tchem

Family: Enzyme

Novelty: 0.00961721

Score: 0.902

Data Source: STRINGDB

MAN2B1

Tchem

Family: Enzyme

Novelty: 0.0051017

Score: 0.902

Data Source: STRINGDB

Publication Statistics

PubMed Score  33.76

PubMed score by year

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PubTator Score  41.23

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Mitochondrion
Phosphoprotein
Polymorphism
Reference proteome