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Tchem
BACE2
Beta-secretase 2

Protein Summary
Description
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328735
  • ENSP00000333854
  • ENSG00000182240
  • ENST00000330333
  • ENSP00000332979
  • ENST00000347667
  • ENSP00000327528

Symbol
  • AEPLC
  • ALP56
  • ASP21
  • ASP1
  • BAE2
  • DRAP
  • AEPLC
  • ALP56
  • ASP21
  • CDA13
  • CEAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor perturbation
0.84
PubMedID
0.82
protein domain
0.73
gene perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.35   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 491   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.35   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 917
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (79)
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
p_int:  0.989388941
p_ni:  0.010538168
p_wrong:  0.000072891
Score:  0.15
Data Source:  BioPlex,STRINGDB
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.985676949
p_ni:  0.014322989
p_wrong:  6.2e-8
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.983263408
p_ni:  0.016736548
p_wrong:  4.4e-8
Data Source:  BioPlex
CHST6
Tbio
Family:  Enzyme
Novelty:  0.01917947
p_int:  0.982152998
p_ni:  0.017759462
p_wrong:  0.00008754
Score:  0.179
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.979829817
p_ni:  0.019992256
p_wrong:  0.000177927
Data Source:  BioPlex
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.97955462
p_ni:  0.020220774
p_wrong:  0.000224606
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.979019275
p_ni:  0.020955084
p_wrong:  0.000025642
Score:  0.177
Data Source:  BioPlex,STRINGDB
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.977789183
p_ni:  0.022210774
p_wrong:  4.2e-8
Data Source:  BioPlex
IFNE
Tbio
Novelty:  0.01597003
p_int:  0.975479478
p_ni:  0.024356698
p_wrong:  0.000163824
Score:  0.161
Data Source:  BioPlex,STRINGDB
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.972546853
p_ni:  0.02732916
p_wrong:  0.000123987
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
85.2
1
1
0
1.1
80.6
cancer biomarker measurement
1
1
1
74.6
C-peptide measurement
1
1
1
65.6
fasting blood glucose measurement
1
1
1
65.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
85.2
0
1.1
80.6
cancer biomarker measurement
1
74.6
C-peptide measurement
1
65.6
fasting blood glucose measurement
1
65.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-site APP-cleaving enzyme 2
747819
Macaque
beta-site APP-cleaving enzyme 2
715330
Mouse
MGI:1860440
56175
Rat
RGD:1303241
288227
Dog
beta-site APP-cleaving enzyme 2
VGNC:38359
478418
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-site APP-cleaving enzyme 2
Macaque
beta-site APP-cleaving enzyme 2
Mouse
Rat
Dog
beta-site APP-cleaving enzyme 2
Publication Statistics
PubMed Score 168.35
PubMed score by year
PubTator Score 213.92
PubTator score by year
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Related Publications
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PMID
Year
Title