Protein Summary
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000328735
- ENSP00000333854
- ENSG00000182240
- ENST00000330333
- ENSP00000332979
- ENST00000347667
- ENSP00000327528
- AEPLC
- ALP56
- ASP21
- ASP1
- BAE2
- DRAP
- AEPLC
- ALP56
- ASP21
- CDA13
- CEAP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.96 | ||
transcription factor perturbation | 0.84 | ||
PubMedID | 0.82 | ||
protein domain | 0.73 | ||
gene perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 168.35 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 491 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 168.35 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 491 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 917
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (917)
Protein-Protein Interactions (79)
ATP1B3
Family: Transporter
Novelty: 0.06773518
p_int: 0.989388941
p_ni: 0.010538168
p_wrong: 0.000072891
Score: 0.15
Data Source: BioPlex,STRINGDB
MPPE1
Family: Enzyme
Novelty: 0.16027847
p_int: 0.985676949
p_ni: 0.014322989
p_wrong: 6.2e-8
Data Source: BioPlex
ST8SIA4
Family: Enzyme
Novelty: 0.00338436
p_int: 0.983263408
p_ni: 0.016736548
p_wrong: 4.4e-8
Data Source: BioPlex
CHST6
Family: Enzyme
Novelty: 0.01917947
p_int: 0.982152998
p_ni: 0.017759462
p_wrong: 0.00008754
Score: 0.179
Data Source: BioPlex,STRINGDB
TCTN2
Novelty: 0.11617528
p_int: 0.979829817
p_ni: 0.019992256
p_wrong: 0.000177927
Data Source: BioPlex
CD1E
Novelty: 0.00171622
p_int: 0.97955462
p_ni: 0.020220774
p_wrong: 0.000224606
Data Source: BioPlex
CLEC2D
Novelty: 0.02501194
p_int: 0.979019275
p_ni: 0.020955084
p_wrong: 0.000025642
Score: 0.177
Data Source: BioPlex,STRINGDB
TMPRSS11B
Family: Enzyme
Novelty: 1.20690443
p_int: 0.977789183
p_ni: 0.022210774
p_wrong: 4.2e-8
Data Source: BioPlex
IFNE
Novelty: 0.01597003
p_int: 0.975479478
p_ni: 0.024356698
p_wrong: 0.000163824
Score: 0.161
Data Source: BioPlex,STRINGDB
HLA-E
Novelty: 0.00216583
p_int: 0.972546853
p_ni: 0.02732916
p_wrong: 0.000123987
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
KEGG (1)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Alzheimer disease | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Alzheimer disease | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (2)
Components (9)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 2 | 2 | 85.2 | |||||
1 | 1 | 0 | 1.1 | 80.6 | |||||
cancer biomarker measurement | 1 | 1 | 1 | 74.6 | |||||
C-peptide measurement | 1 | 1 | 1 | 65.6 | |||||
fasting blood glucose measurement | 1 | 1 | 1 | 65.6 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 85.2 | |||||
0 | 1.1 | 80.6 | |||||
cancer biomarker measurement | 1 | 74.6 | |||||
C-peptide measurement | 1 | 65.6 | |||||
fasting blood glucose measurement | 1 | 65.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | beta-site APP-cleaving enzyme 2 | 747819 | ||||||
Macaque | beta-site APP-cleaving enzyme 2 | 715330 | ||||||
Mouse | MGI:1860440 | 56175 | ||||||
Rat | RGD:1303241 | 288227 | ||||||
Dog | beta-site APP-cleaving enzyme 2 | VGNC:38359 | 478418 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | beta-site APP-cleaving enzyme 2 | |||||
Macaque | beta-site APP-cleaving enzyme 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | beta-site APP-cleaving enzyme 2 | |||||
Publication Statistics
PubMed Score 168.35
PubMed score by year
PubTator Score 213.92
PubTator score by year
Related Publications
Text Mined References (57)
GeneRif Annotations (35)
Items per page:
0 of 0
PMID | Year | Title |
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