Tchem BACE2 Beta-secretase 2

Protein Summary

Description

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q9Y5Z0
• A8K7P1
• Q5DIH8
• Q8N2D4
• Q9H2V8
• Q9NZL1
• Q9NZL2
• Q9UJT6

Gene Name

• BACE2

Ensembl ID

• ENST00000328735
• ENSP00000333854
• ENSG00000182240
• ENST00000330333
• ENSP00000332979
• ENST00000347667
• ENSP00000327528

Symbol

• AEPLC
• ALP56
• ASP21
• ASP1
• BAE2
• DRAP
• AEPLC
• ALP56
• ASP21
• CDA13
• CEAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
transcription factor perturbation	0.84
PubMedID	0.82
protein domain	0.73
gene perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Aspartic Protease / Beta-secretase 2

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Beta-secretase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.99   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 491   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.99   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 933

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0