Tchem BACE2 Beta-secretase 2

Protein Summary

Description

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q9Y5Z0
• A8K7P1
• Q5DIH8
• Q8N2D4
• Q9H2V8
• Q9NZL1
• Q9NZL2
• Q9UJT6

Gene Name

• BACE2

Ensembl ID

• ENST00000328735
• ENSP00000333854
• ENSG00000182240
• ENST00000330333
• ENSP00000332979
• ENST00000347667
• ENSP00000327528

Symbol

• AEPLC
• ALP56
• ASP21
• ASP1
• BAE2
• DRAP
• AEPLC
• ALP56
• ASP21
• CDA13
• CEAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
transcription factor perturbation	0.84
PubMedID	0.82
protein domain	0.73
gene perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Aspartic Protease / Beta-secretase 2

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Beta-secretase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.35   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 491   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.35   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 917

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (917)

Explore Active Ligands

1 – 10 of 917

CHEMBL4564735

BACE2Tchem Enzyme

pIC50 : 9.1

CHEMBL1097342

BACE2Tchem Enzyme

pKi : 9.1

CHEMBL3354688

BACE2Tchem Enzyme

pKi : 6.18

CHEMBL509210

BACE2Tchem Enzyme

pKi : 8.52

CHEMBL1210434

BACE2Tchem Enzyme

pIC50 : 8.4

CHEMBL270359

BACE2Tchem Enzyme

pKi : 8.3

CHEMBL507651

BACE2Tchem Enzyme

pKi : 8.7

CHEMBL403727

BACE2Tchem Enzyme

pKi : 7.62

CHEMBL4088234

BACE2Tchem Enzyme

pIC50 : 10.62

CHEMBL4098403

BACE2Tchem Enzyme

pIC50 : 7.75

Protein-Protein Interactions (79)

Explore Interacting Targets

1 – 10 of 79

• See Interactions on String-DB

ATP1B3

Tclin

Family:  Transporter

Novelty:  0.06773518

p_int:  0.989388941

p_ni:  0.010538168

p_wrong:  0.000072891

Score:  0.15

Data Source:  BioPlex,STRINGDB

MPPE1

Tbio

Family:  Enzyme

Novelty:  0.16027847

p_int:  0.985676949

p_ni:  0.014322989

p_wrong:  6.2e-8

Data Source:  BioPlex

ST8SIA4

Tbio

Family:  Enzyme

Novelty:  0.00338436

p_int:  0.983263408

p_ni:  0.016736548

p_wrong:  4.4e-8

Data Source:  BioPlex

CHST6

Tbio

Family:  Enzyme

Novelty:  0.01917947

p_int:  0.982152998

p_ni:  0.017759462

p_wrong:  0.00008754

Score:  0.179

Data Source:  BioPlex,STRINGDB

TCTN2

Tbio

Novelty:  0.11617528

p_int:  0.979829817

p_ni:  0.019992256

p_wrong:  0.000177927

Data Source:  BioPlex

CD1E

Tbio

Novelty:  0.00171622

p_int:  0.97955462

p_ni:  0.020220774

p_wrong:  0.000224606

Data Source:  BioPlex

CLEC2D

Tbio

Novelty:  0.02501194

p_int:  0.979019275

p_ni:  0.020955084

p_wrong:  0.000025642

Score:  0.177

Data Source:  BioPlex,STRINGDB

TMPRSS11B

Tdark

Family:  Enzyme

Novelty:  1.20690443

p_int:  0.977789183

p_ni:  0.022210774

p_wrong:  4.2e-8

Data Source:  BioPlex

IFNE

Tbio

Novelty:  0.01597003

p_int:  0.975479478

p_ni:  0.024356698

p_wrong:  0.000163824

Score:  0.161

Data Source:  BioPlex,STRINGDB

HLA-E

Tbio

Novelty:  0.00216583

p_int:  0.972546853

p_ni:  0.02732916

p_wrong:  0.000123987

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

KEGG (1)

PathwayCommons (2)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Alzheimer disease	171 targets	path:hsa05010

Name	Explore in Pharos	Explore in Source
Alzheimer disease	171 targets	path:hsa05010

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (2)

Components (9)

Processes (8)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
aspartic-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
amyloid-beta binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	2	2	2		85.2
cutaneous melanoma	EFO_0000389	1	1	0	1.1	80.6
cancer biomarker measurement	EFO_0005127	1	1	1		74.6
C-peptide measurement	EFO_0005187	1	1	1		65.6
fasting blood glucose measurement	EFO_0004465	1	1	1		65.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	2		85.2
cutaneous melanoma	EFO_0000389	0	1.1	80.6
cancer biomarker measurement	EFO_0005127	1		74.6
C-peptide measurement	EFO_0005187	1		65.6
fasting blood glucose measurement	EFO_0004465	1		65.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Aspartyl protease
Autocatalytic cleavage
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Endosome

GWAS Trait Find Similar Targets

No Header	No Header
body height
body mass index
C-peptide measurement
cancer biomarker measurement
cognitive function measurement
cutaneous melanoma
fasting blood glucose measurement
glucose tolerance test
intelligence
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
integument phenotype
pigmentation phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	beta-site APP-cleaving enzyme 2		747819
Macaque	beta-site APP-cleaving enzyme 2		715330
Mouse	beta-site APP-cleaving enzyme 2	MGI:1860440	56175
Rat	beta-site APP-cleaving enzyme 2	RGD:1303241	288227
Dog	beta-site APP-cleaving enzyme 2	VGNC:38359	478418

Species	Name	OMA	EggNOG	Inparanoid
Chimp	beta-site APP-cleaving enzyme 2
Macaque	beta-site APP-cleaving enzyme 2
Mouse	beta-site APP-cleaving enzyme 2
Rat	beta-site APP-cleaving enzyme 2
Dog	beta-site APP-cleaving enzyme 2

Publication Statistics

PubMed Score 168.35

PubMed score by year

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PubTator Score 213.92

PubTator score by year

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Related Publications

Text Mined References (57)

GeneRif Annotations (35)

Items per page:

10

0 of 0

PMID	Year	Title