You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
BACE2
Beta-secretase 2

Protein Summary
Description
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328735
  • ENSP00000333854
  • ENSG00000182240
  • ENST00000330333
  • ENSP00000332979
  • ENST00000347667
  • ENSP00000327528

Symbol
  • AEPLC
  • ALP56
  • ASP21
  • ASP1
  • BAE2
  • DRAP
  • AEPLC
  • ALP56
  • ASP21
  • CDA13
  • CEAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor perturbation
0.84
PubMedID
0.82
protein domain
0.73
gene perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.99   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 491   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.99   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 933
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0