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Tclin
SCN10A
Sodium channel protein type 10 subunit alpha

Protein Summary
Description
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000449082
  • ENSP00000390600
  • ENSG00000185313
  • ENST00000644826
  • ENSP00000494789

Symbol
  • PN3
  • SNS
  • hPN3
  • FEPS2
  • Nav1.8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
molecular function
0.84
drug
0.77
protein domain
0.73
small molecule perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 968.5   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 968.5   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 200
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (125)
1 – 10 of 125
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
Score:  0.972
Data Source:  STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
Score:  0.956
Data Source:  STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
Score:  0.951
Data Source:  STRINGDB
SCN4B
Tbio
Family:  IC
Novelty:  0.02505113
Score:  0.947
Data Source:  STRINGDB
SCN5A
Tclin
Family:  IC
Novelty:  0.00050944
Score:  0.946
Data Source:  STRINGDB
ANK1
Tbio
Novelty:  0.00225305
Score:  0.936
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.934
Data Source:  STRINGDB
ANK3
Tbio
Novelty:  0.00429246
Score:  0.934
Data Source:  STRINGDB
NFASC
Tbio
Novelty:  0.00545331
Score:  0.917
Data Source:  STRINGDB
SCLT1
Tbio
Novelty:  0.10969171
Score:  0.914
Data Source:  STRINGDB
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
8
9
0
3.6
99.3
electrocardiography
4
6
146
5.2
99
QT interval
3
4
2
3.4
97.3
2
1
0
2.5
86.1
heart rate
1
1
0
10
85.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
0
3.6
99.3
electrocardiography
146
5.2
99
QT interval
2
3.4
97.3
0
2.5
86.1
heart rate
0
10
85.3
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 10
VGNC:12180
460274
Macaque
sodium voltage-gated channel alpha subunit 10
694962
Mouse
MGI:108029
20264
Rat
RGD:3629
29571
Dog
sodium voltage-gated channel alpha subunit 10
VGNC:45913
477026
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 10
Macaque
sodium voltage-gated channel alpha subunit 10
Mouse
Rat
Dog
sodium voltage-gated channel alpha subunit 10
Publication Statistics
PubMed Score 968.50
PubMed score by year
PubTator Score 283.79
PubTator score by year
Patents
Patents by year